Shiota Masakazu, Magnuson Mark A
Department of Molecular Physiology and Biophysics and Vanderbilt Center for Stem Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.
J Clin Invest. 2008 Mar;118(3):841-4. doi: 10.1172/JCI35137.
In this issue of the JCI, Denechaud et al. report studies investigating the role of the liver X receptors (LXRs) LXRalpha and LXRbeta in carbohydrate sensing by the liver (see the related article beginning on page 956). The results of this study, which utilized LXRalpha/beta double-KO mice, strongly contradict a recent Nature report that proposed that LXRalpha/beta sense glucose independent of metabolic flux. The reported findings further support a key role for the carbohydrate-responsive element-binding protein (ChREBP) in the regulation of lipogenic genes by glucose and dietary carbohydrates.
在本期《临床研究杂志》（JCI）中，德内肖等人报告了关于肝脏X受体（LXRs）中的LXRα和LXRβ在肝脏碳水化合物感知中作用的研究（见第956页开始的相关文章）。这项利用LXRα/β双敲除小鼠的研究结果，与《自然》杂志最近一篇提出LXRα/β独立于代谢通量感知葡萄糖的报告形成了强烈矛盾。报告的研究结果进一步支持了碳水化合物反应元件结合蛋白（ChREBP）在葡萄糖和膳食碳水化合物对脂肪生成基因调控中的关键作用。
