肝脏葡萄糖感知：通量重要吗？
Hepatic glucose sensing: does flux matter?
作者信息
Shiota Masakazu, Magnuson Mark A
机构信息
Department of Molecular Physiology and Biophysics and Vanderbilt Center for Stem Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.
出版信息
J Clin Invest. 2008 Mar;118(3):841-4. doi: 10.1172/JCI35137.
Abstract
In this issue of the JCI, Denechaud et al. report studies investigating the role of the liver X receptors (LXRs) LXRalpha and LXRbeta in carbohydrate sensing by the liver (see the related article beginning on page 956). The results of this study, which utilized LXRalpha/beta double-KO mice, strongly contradict a recent Nature report that proposed that LXRalpha/beta sense glucose independent of metabolic flux. The reported findings further support a key role for the carbohydrate-responsive element-binding protein (ChREBP) in the regulation of lipogenic genes by glucose and dietary carbohydrates.
摘要
在本期《临床研究杂志》（JCI）中，德内肖等人报告了关于肝脏X受体（LXRs）中的LXRα和LXRβ在肝脏碳水化合物感知中作用的研究（见第956页开始的相关文章）。这项利用LXRα/β双敲除小鼠的研究结果，与《自然》杂志最近一篇提出LXRα/β独立于代谢通量感知葡萄糖的报告形成了强烈矛盾。报告的研究结果进一步支持了碳水化合物反应元件结合蛋白（ChREBP）在葡萄糖和膳食碳水化合物对脂肪生成基因调控中的关键作用。
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Hepatic glucose sensing: does flux matter?肝脏葡萄糖感知：通量重要吗？
J Clin Invest. 2008 Mar;118(3):841-4. doi: 10.1172/JCI35137.
2
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Nuclear receptor liver X receptor is O-GlcNAc-modified in response to glucose.核受体肝 X 受体在响应葡萄糖时被 O-GlcNAc 修饰。
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本文引用的文献
1
ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver.在小鼠肝脏中，诱导葡萄糖调节基因需要ChREBP，而非肝X受体（LXRs）。
J Clin Invest. 2008 Mar;118(3):956-64. doi: 10.1172/JCI34314.
2
Carbohydrate-response element-binding protein deletion alters substrate utilization producing an energy-deficient liver.碳水化合物反应元件结合蛋白缺失会改变底物利用，导致肝脏能量缺乏。
J Biol Chem. 2008 Jan 18;283(3):1670-1678. doi: 10.1074/jbc.M706540200. Epub 2007 Nov 27.
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Sweet dreams for LXR.祝肝脏X受体有好梦。
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4
The nuclear receptor LXR is a glucose sensor.核受体肝X受体是一种葡萄糖传感器。
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5
The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR.肝脏X受体（LXR）与肝脏脂肪生成。碳水化合物反应元件结合蛋白是LXR的一个靶基因。
J Biol Chem. 2007 Jan 5;282(1):743-51. doi: 10.1074/jbc.M605023200. Epub 2006 Nov 14.
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Liver X receptors as integrators of metabolic and inflammatory signaling.肝脏X受体作为代谢和炎症信号的整合者。
J Clin Invest. 2006 Mar;116(3):607-14. doi: 10.1172/JCI27883.
7
Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element-binding protein-1c.胰岛素和肝脏X受体在固醇调节元件结合蛋白-1c的诱导和裂解中的不同作用。
Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):791-6. doi: 10.1073/pnas.0405067102. Epub 2005 Jan 6.
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Role of the Arabidopsis glucose sensor HXK1 in nutrient, light, and hormonal signaling.拟南芥葡萄糖传感器HXK1在营养、光照和激素信号传导中的作用。
Science. 2003 Apr 11;300(5617):332-6. doi: 10.1126/science.1080585.
9
Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver.磷酸木酮糖通过大鼠肝脏中磷酸木酮糖激活的蛋白磷酸酶介导葡萄糖诱导的脂肪生成。
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