Sung J H, Hayano M, Mastri A R, Okagaki T
J Neuropathol Exp Neurol. 1976 Sep-Oct;35(5):541-59. doi: 10.1097/00005072-197609000-00006.
A 60-year old man, eight weeks after being bitten on his finger by a stray cat, developed symptoms and signs of rabies which progressed rapidly over the next two weeks and he died of respiratory failure. Pathological examination revealed characteristic cytoplasmic inclusions in neurons of various parts of the central nervous system and the dorsal spinal and sympathetic ganglia. The diagnosis of rabies was confirmed by direct fluorescent antibody staining of the brain tissue obtained at autopsy. On histological examination, most, if not all, of the neuronal cytoplasmic inclusions were eosinophilic and homogeneous and lacked the basophilic inner granules or bodies characteristic of Negri bodies. Nevertheless, they were ultrastructurally identical with Negri bodies by virtue of being made up of finely fibrillar matrix and virus and/or related particles in varying numbers. This indicates that ultrastructurally typica Negri bodies may or may not have the histologically visible basophilic inner bodies depending upon the degree of virus replication. In light of the ultrastructural evidence, lyssa bodies described in rabies in the past may represent Negri bodies without histologically recognizable inner bodies or cytoplasmic inclusions unrelated to rabies, occurring ordinarily in normal or degenerating neurons. It is, therefore, suggested that the term, lyssa body, is obsolete and should no longer be used.
一名60岁男性，在被一只流浪猫咬伤手指八周后，出现狂犬病症状和体征，在接下来的两周内迅速进展，最终死于呼吸衰竭。病理检查显示中枢神经系统各部位、背侧脊髓和交感神经节的神经元中存在特征性的胞质内包涵体。尸检获取的脑组织经直接荧光抗体染色后确诊为狂犬病。组织学检查发现，大多数（即便不是全部）神经元胞质内包涵体呈嗜酸性且均匀一致，缺乏内基小体特有的嗜碱性颗粒或小体。然而，从超微结构来看，它们与内基小体相同，均由细纤维状基质以及数量不等的病毒和/或相关颗粒组成。这表明，根据病毒复制程度，超微结构典型的内基小体在组织学上可能有或没有可见的嗜碱性内体。鉴于超微结构证据，过去在狂犬病中描述的狂犬病包涵体可能代表没有组织学可识别内体的内基小体，或者是与狂犬病无关的胞质内包涵体，通常出现在正常或退变的神经元中。因此，有人建议，“狂犬病包涵体”这一术语已过时，不应再使用。
