Peredo H A, Mayer M A, Carranza A, Puyó A M
Cátedras de Anatomía Humana (Macro y Microscópica) y Farmacotecnia I, Facultad de Farmacia y Bioquímica, Instituto de Morfología JJ Naón, Argentina.
Clin Exp Hypertens. 2008 Feb;30(2):159-69. doi: 10.1080/10641960801946889.
This study analyzes the effects of losartan (AT1 blocker) and pioglitazone (insulin sensitizer), alone and in combination, in the fructose-overloaded rat, a model of metabolic syndrome. All treatments (nine weeks) reduced blood pressure and triglyceridemia and also restored the diminished release of vasodilator prostaglandins (prostacyclin in aorta and mesenteric vascular bed and prostaglandin E(2) in the latter). Pioglitazone, alone and in combination with losartan, reduced the release of the vasoconstrictor thromboxane in controls and fructose rats in both vascular preparations. In conclusion, although combination therapy and single treatments exerted similar effects, there may still be some advantage to the combined treatment.
本研究分析了氯沙坦（AT1受体阻滞剂）和吡格列酮（胰岛素增敏剂）单独及联合使用对果糖超载大鼠（一种代谢综合征模型）的影响。所有治疗（为期九周）均降低了血压和甘油三酯血症，还恢复了血管舒张性前列腺素释放的减少（主动脉和肠系膜血管床中的前列环素以及后者中的前列腺素E2）。在对照大鼠和果糖大鼠的两种血管制剂中，吡格列酮单独使用以及与氯沙坦联合使用均降低了血管收缩剂血栓素的释放。总之，尽管联合治疗和单一治疗产生了相似的效果，但联合治疗可能仍具有一些优势。
