Cryan Lorna M, Paraoan Luminita, Hiscott Paul, Damato Bertil E, Grierson Ian, Gray Donna, Farrell Michael, Doherty Glen A, Fitzgerald Desmond J, O'Brien Colm
School of Medicine and Medical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, and Department of Ophthalmology, Mater Misericordiae Hospital, Dublin, Ireland.
Curr Eye Res. 2008 Feb;33(2):177-84. doi: 10.1080/02713680701867908.
The expression of cyclooxygenase-2 (COX-2) and its prognostic value in uveal melanoma was examined.
Paraffin-embedded sections from 32 clinicopathologically well-characterized cases of primary uveal melanoma were immunohistochemically stained for COX-2. COX-2 expression was evaluated in terms of both the intensity and the extent of staining for each tumor. A COX-2 score encompassing both intensity and extent was also calculated for each specimen.
29 specimens (90.6%) contained moderate or intense positive immunoreactivity for COX-2. A statistically significant association (p<0.05) between COX-2 expression (intensity and score) and metastatic death was established.
Upregulation of COX-2 expression appears to be associated with poor prognosis in uveal melanoma.
研究环氧化酶-2（COX-2）在葡萄膜黑色素瘤中的表达及其预后价值。
对32例临床病理特征明确的原发性葡萄膜黑色素瘤石蜡包埋切片进行COX-2免疫组织化学染色。根据每个肿瘤的染色强度和范围评估COX-2表达。还为每个标本计算了一个包含强度和范围的COX-2评分。
29个标本（90.6%）对COX-2呈中度或强阳性免疫反应。COX-2表达（强度和评分）与转移性死亡之间建立了统计学上的显著关联（p<0.05）。
COX-2表达上调似乎与葡萄膜黑色素瘤的预后不良有关。
