Kapadia Farzana, Vlahov David, Wu Yingfeng, Cohen Mardge H, Greenblatt Ruth M, Howard Andrea A, Cook Judith A, Goparaju Lakshmi, Golub Elizabeth, Richardson Jean, Wilson Tracey E
Center for Urban Epidemiologic Studies, New York Academy of Medicine, New York, New York, USA.
Am J Drug Alcohol Abuse. 2008;34(2):161-70. doi: 10.1080/00952990701877052.
Methadone maintenance is associated with improved adherence to antiretroviral therapies among HIV-positive illicit drug users; however, little information exists on whether adherence is associated with different drug abuse treatment modalities. Using longitudinal data from the Women's Interagency HIV Study, we evaluated the relationship between drug abuse treatment modality and adherence to antiretroviral therapies. In prospective analyses, individuals who reported accessing any drug abuse treatment program were more likely to report adherence to antiretroviral regimens > or = 95% of the time (AOR = 1.39, 95% CI = 1.01-1.92). Involvement in either a medication-based or medication-free program was similarly associated with improved adherence. Drug abuse treatment programs, irrespective of modality, are associated with improved adherence to antiretroviral therapies among drug users. Concerted efforts to enroll individuals with drug use histories in treatment programs are warranted to improve HIV disease outcomes.
美沙酮维持治疗与提高艾滋病毒阳性非法药物使用者对抗逆转录病毒疗法的依从性相关；然而，关于依从性是否与不同的药物滥用治疗方式相关的信息却很少。利用妇女机构间艾滋病毒研究的纵向数据，我们评估了药物滥用治疗方式与对抗逆转录病毒疗法的依从性之间的关系。在前瞻性分析中，报告接受过任何药物滥用治疗项目的个体更有可能报告对抗逆转录病毒治疗方案的依从性在95%及以上（调整后比值比=1.39，95%置信区间=1.01-1.92）。参与基于药物或无药物的项目同样与依从性提高相关。无论治疗方式如何，药物滥用治疗项目都与提高吸毒者对抗逆转录病毒疗法的依从性相关。有必要齐心协力让有吸毒史的个体参加治疗项目，以改善艾滋病毒疾病的治疗结果。
