Yao Yu-Hua, Dai Qi, Nan Xu-Ying, He Ping-An, Nie Zuo-Ming, Zhou Song-Ping, Zhang Yao-Zhou
College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, People's Republic of China.
J Comput Chem. 2008 Jul 30;29(10):1632-9. doi: 10.1002/jcc.20922.
On the basis of a class of 2D graphical representations of DNA sequences, sensitivity analysis has been performed, showing the high-capability of the proposed representations to take into account small modifications of the DNA sequences. And sensitivity analysis also indicates that the absolute differences of the leading eigenvalues of the L/L matrices associated with DNA increase with the increase of the number of the base mutations. Besides, we conclude that the similarity analysis method based on the correlation angles can better eliminate the effects of the lengths of DNA sequences if compared with the method using the Euclidean distances. As application, the examination of similarities/dissimilarities among the coding sequences of the first exon of beta-globin gene of different species has been performed by our method, and the reasonable results verify the validity of our method.
基于一类DNA序列的二维图形表示，进行了敏感性分析，结果表明所提出的表示方法具有很高的能力来考虑DNA序列的微小变化。敏感性分析还表明，与DNA相关的L/L矩阵的主导特征值的绝对差异随着碱基突变数量的增加而增大。此外，我们得出结论，与使用欧几里得距离的方法相比，基于相关角的相似性分析方法能够更好地消除DNA序列长度的影响。作为应用，我们的方法对不同物种β-珠蛋白基因第一个外显子编码序列之间的相似性/差异性进行了检测，合理的结果验证了我们方法的有效性。
