类风湿关节炎患者的脂蛋白(a)、脂质和脂蛋白
Lipoprotein (a), lipids, and lipoproteins in patients with rheumatoid arthritis.
作者信息
Rantapää-Dahlqvist S, Wållberg-Jonsson S, Dahlén G
机构信息
Department of Rheumatology, University Hospital, Umeå, Sweden.
出版信息
Ann Rheum Dis. 1991 Jun;50(6):366-8. doi: 10.1136/ard.50.6.366.
Abstract
Lipoprotein (a), (Lp(a)), an independent atherogenic factor, was significantly increased in 93 patients with classical, seropositive rheumatoid arthritis of median disease activity. In the patients with Lp(a) concentrations above the upper reference value of 480 mg/l there was a significant correlation between Lp(a) and the concentration of orosomucoid, erythrocyte sedimentation rate, and the platelet count. The plasma concentrations of cholesterol and high density lipoprotein-cholesterol in both male and female patients were significantly lower than in controls. Apolipoprotein B and apolipoprotein AI in the patients correlated significantly with total cholesterol and high density lipoprotein-cholesterol respectively.
摘要
脂蛋白(a) [Lp(a)] 是一种独立的致动脉粥样硬化因子，在93例处于疾病活动中位数的典型、血清反应阳性类风湿关节炎患者中显著升高。在Lp(a)浓度高于480mg/l的参考上限值的患者中，Lp(a)与血清类黏蛋白浓度、红细胞沉降率及血小板计数之间存在显著相关性。男性和女性患者的血浆胆固醇和高密度脂蛋白胆固醇浓度均显著低于对照组。患者中的载脂蛋白B和载脂蛋白AI分别与总胆固醇和高密度脂蛋白胆固醇显著相关。
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