一种由二卤代苯简便一锅法制备有机硒代三氟硼酸盐及其交叉偶联反应。

A facile one-pot preparation of organoselanyltrifluoroborates from dihalobenzenes and their cross-coupling reaction.

作者信息

Ahn Hong Ryul, Cho Young Ae, Kim Dong-Su, Chin Jungwook, Gyoung Young-Soo, Lee Seokjoon, Kang Heonjoong, Ham Jungyeob

机构信息

Korea Institute of Science and Technology, 290 Daejeon-dong, Gangneung 210-340, Korea.

出版信息

Org Lett. 2009 Jan 15;11(2):361-4. doi: 10.1021/ol8025999.

DOI:10.1021/ol8025999

PMID:19072318

Abstract

Potassium organoselanyltrifluoroborates have been prepared from the corresponding dihalobenzene compounds in 56-92% yields through a facile one-pot, multicomponent reaction. The microwave-promoted Suzuki-Miyaura cross-coupling reaction of these substrates with various aryl and alkenyl bromides in the presence of 3.0 mol % of Pd(PPh(3))(4) and 3.0 equiv of K(2)CO(3) in aqueous 1,4-dioxane at 130 degrees C provided the desired compounds in 54-91% yields.

摘要

通过简便的一锅多组分反应，已从相应的二卤代苯化合物制备出有机硒基三氟硼酸钾，产率为56 - 92%。在3.0 mol%的Pd(PPh(3))(4)和3.0当量的K(2)CO(3)存在下，于130℃的1,4 - 二氧六环水溶液中，这些底物与各种芳基和烯基溴化物进行微波促进的铃木 - 宫浦交叉偶联反应，以54 - 91%的产率得到所需化合物。