间充质干细胞在再生医学中的作用：在骨与软骨修复中的应用
Role of mesenchymal stem cells in regenerative medicine: application to bone and cartilage repair.
作者信息
Granero-Molto Froilan, Weis Jared A, Longobardi Lara, Spagnoli Anna
机构信息
University of North Carolina at Chapel Hill, Division of Endocrinology, Department of Pediatrics, 3341 Medical Biomolecular Research Building, 103 Mason Farm Road Campus Box: 7039, Chapel Hill North Carolina 27599-7239, USA.
出版信息
Expert Opin Biol Ther. 2008 Mar;8(3):255-68. doi: 10.1517/14712598.8.3.255.
BACKGROUND
Mesenchymal stem cells (MSC) are multipotent cells with the ability to differentiate into mesenchyme-derived cells including osteoblasts and chondrocytes.
OBJECTIVE
To provide an overview and expert opinion on the in vivo ability of MSC to home into tissues, their regenerative properties and potential applications for cell-based therapies to treat bone and cartilage disorders.
METHODS
Data sources including the PubMed database, abstract booklets and conference proceedings were searched for publications pertinent to MSC and their properties with emphasis on the in vivo studies and clinical use in cartilage and bone regeneration and repair. The search included the most current information possible.
CONCLUSION
MSC can migrate to injured tissues and some of their reparative properties are mediated by paracrine mechanisms including their immunomodulatory actions. MSC possess a critical potential in regenerative medicine for the treatment of skeletal diseases, such as osteoarthritis or fracture healing failure, where treatments are partially effective or palliative.
背景
间充质干细胞（MSC）是多能细胞，具有分化为包括成骨细胞和软骨细胞在内的间充质来源细胞的能力。
目的
综述间充质干细胞归巢至组织的体内能力、其再生特性以及基于细胞的疗法治疗骨和软骨疾病的潜在应用，并给出专家意见。
方法
检索包括PubMed数据库、摘要手册和会议论文集在内的数据源，以查找与间充质干细胞及其特性相关的出版物，重点关注体内研究以及在软骨和骨再生与修复中的临床应用。检索尽可能涵盖最新信息。
结论
间充质干细胞可迁移至受损组织，其一些修复特性由旁分泌机制介导，包括免疫调节作用。间充质干细胞在再生医学中对于治疗骨骼疾病具有关键潜力，如骨关节炎或骨折愈合失败，这些疾病的治疗部分有效或仅为姑息治疗。
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