Non-canonical poly(A) polymerase in mammalian gametogenesis.

Polyadenylation of mRNA precursors initially occurs in the nucleus of eukaryotic cells, and the polyadenylated mRNAs are then transported into the cytoplasm. Because the length of the poly(A) tail is implicated in various aspects of mRNA metabolism, including the transport into the cytoplasm, stability, and translational control, processing of mRNA precursors at the 3'-end is important for post-transcriptional gene regulation. In particular, the lengthening, maintenance, and shortening of poly(A) tails in the cytoplasm are all essential for modulation of gametogenesis. Here we focus on the functional roles of mouse Tpap and Gld-2 in spermatogenesis and oocyte maturation, respectively.