Lee Ji-Soo, Chung Donghwa, Lee Hyeon Gyu
Department of Food and Nutrition, Hanyang University, 17 Haengdang-dong, Seongdong-gu, Seoul 133-791, Republic of Korea.
Int J Biol Macromol. 2008 May 1;42(4):340-7. doi: 10.1016/j.ijbiomac.2008.01.003. Epub 2008 Jan 18.
Response surface methodology was used to optimize bead preparation conditions, including CaCl(2) concentration (X(1)), hydroxypropylmethylcellulose concentration (X(2)), and bead-hardening time (X(3)), for the sustained-release of catechin from the calcium pectinate gel beads reinforced with liposomes and hydroxypropylmethylcellulose into simulated gastric fluid (SGF) and intestinal fluid (SIF). The optimized values of X(1), X(2), and X(3) were found to be 5.82%, 0.08%, and 10.29min, respectively. The beads prepared according to the optimized conditions released only about half of the entrapped catechin into SGF while most of the entrapped catechin was released into SIF after 24h incubation.
采用响应面法优化了脂质体和羟丙基甲基纤维素增强的果胶钙凝胶珠中儿茶素向模拟胃液（SGF）和肠液（SIF）中缓释的微珠制备条件，包括氯化钙浓度（X(1)）、羟丙基甲基纤维素浓度（X(2)）和微珠硬化时间（X(3)）。发现X(1)、X(2)和X(3)的优化值分别为5.82%、0.08%和10.29分钟。按照优化条件制备的微珠在SGF中仅释放了约一半包封的儿茶素，而在孵育24小时后，大部分包封的儿茶素释放到了SIF中。
