Sturges Amber, Butt Amir L, Lai James E, Chodosh James
Public Health in Ophthalmology Working Group, Dean A. McGee Eye Institute, Oklahoma City, Oklahoma, USA.
Ophthalmology. 2008 Aug;115(8):1297-302, 1302.e1. doi: 10.1016/j.ophtha.2008.01.006. Epub 2008 Feb 21.
To describe the successful treatment and long-term outcomes of primary ocular surface squamous neoplasia (OSSN) with topical interferon alfa-2b or surgical excision.
Retrospective, comparative, interventional case series.
Twenty-nine consecutive patients with OSSN never before treated.
Patients with primary OSSN chose topical interferon alfa-2b or excision with wide surgical margins, with crossover to surgery in those interferon-treated patients whose OSSN failed to regress within 2 months after beginning therapy.
Successful resolution of clinical disease at 2 months after topical interferon treatment and time to recurrence after either topical interferon or surgical excision.
Of 29 patients with primary OSSN, 15 elected topical interferon and 14 chose surgical excision. Two patients in the interferon group subsequently underwent surgical excision for apparent lack of response to interferon. No patient in either group developed a recurrence during the study period (disease-free follow-up: interferon group, mean, 35.6 months [95% confidence interval, 21.9-49.3]; surgery group, mean, 35.6 months [22.9-48.3]).
Both topical interferon alfa-2b and aggressive surgical excision appear to be effective for primary OSSN.
描述采用局部应用干扰素α-2b或手术切除治疗原发性眼表鳞状上皮肿瘤（OSSN）的成功经验及长期疗效。
回顾性、对比性、干预性病例系列研究。
29例未经治疗的连续性OSSN患者。
原发性OSSN患者选择局部应用干扰素α-2b或手术切除并保证手术切缘足够宽，对于接受干扰素治疗但在开始治疗后2个月内OSSN未消退的患者则改为手术治疗。
局部应用干扰素治疗2个月后临床疾病的成功缓解情况以及局部应用干扰素或手术切除后的复发时间。
29例原发性OSSN患者中，15例选择局部应用干扰素，14例选择手术切除。干扰素组有2例患者因对干扰素明显无反应而随后接受了手术切除。在研究期间两组均无患者复发（无病随访时间：干扰素组平均35.6个月[95%可信区间，21.9 - 49.3]；手术组平均35.6个月[22.9 - 48.3]）。
局部应用干扰素α-2b和积极的手术切除对于原发性OSSN似乎均有效。
