Verwoerd-Dikkeboom C M, Koning A H J, van der Spek P J, Exalto N, Steegers E A P
Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, PO Box 2040, Erasmus MC, University Medical Centre Rotterdam, 3000 CA Rotterdam, The Netherlands.
Hum Reprod. 2008 Jul;23(7):1479-84. doi: 10.1093/humrep/den023. Epub 2008 Feb 21.
The aim of this study was to demonstrate that Carnegie Stages could be assigned to embryos visualized with a 3D virtual reality system.
We analysed 48 3D ultrasound scans of 19 IVF/ICSI pregnancies at 7-10 weeks' gestation. These datasets were visualized as 3D 'holograms' in the BARCO I-Space virtual reality system. Embryos were staged according to external morphological features (i.e. mainly limb development). After staging, the crown rump length (CRL) was measured. Stage and CRL were compared with gestational age based on the date of oocyte retrieval and with the classical data on embryology from the Carnegie Collection.
Embryonic staging was relatively easy because the I-Space allows depth perception, which helps in the estimation of size and position. The presumed stages corresponded well with the measured CRL. However, in 28 out of 48 cases, the stages seemed to have been reached earlier than previously described for the Carnegie Collection.
The I-Space, tentatively named Virtual Embryoscopy, is a promising non-invasive tool for early pregnancy evaluation. Combining embryonic growth with embryonic development opens a new area to study the relationship between embryonic growth, development and morphology, as well as second and third trimester pregnancy complications.
本研究的目的是证明可以将卡内基分期应用于通过三维虚拟现实系统可视化的胚胎。
我们分析了19例体外受精/卵胞浆内单精子注射妊娠在孕7至10周时的48次三维超声扫描。这些数据集在巴可I-Space虚拟现实系统中被可视化为三维“全息图”。根据外部形态特征（即主要是肢体发育）对胚胎进行分期。分期后，测量顶臀长度（CRL）。将分期和CRL与基于取卵日期的孕周以及卡内基胚胎学经典数据进行比较。
胚胎分期相对容易，因为I-Space提供深度感知，有助于估计大小和位置。推测的分期与测量的CRL吻合良好。然而，在48例中的28例中，达到的分期似乎比卡内基胚胎学经典数据中先前描述的要早。
I-Space（暂命名为虚拟胚胎镜检查）是一种很有前景的用于早期妊娠评估的非侵入性工具。将胚胎生长与胚胎发育相结合，为研究胚胎生长、发育与形态之间的关系以及孕中期和孕晚期妊娠并发症开辟了一个新领域。
