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Dual therapy with statins and antioxidants is superior to statins alone in decreasing the risk of cardiovascular disease in a subgroup of middle-aged individuals with both diabetes mellitus and the haptoglobin 2-2 genotype.

作者信息

Blum Shany, Milman Uzi, Shapira Chen, Miller-Lotan Rachel, Bennett Lawrence, Kostenko Maria, Landau Michele, Keidar Shlomo, Levy Yishai, Khemlin Alexander, Radan Arman, Levy Andrew P

出版信息

Arterioscler Thromb Vasc Biol. 2008 Mar;28(3):e18-20. doi: 10.1161/ATVBAHA.107.159905.

DOI:10.1161/ATVBAHA.107.159905
PMID:18296583
Abstract
摘要

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Dual therapy with statins and antioxidants is superior to statins alone in decreasing the risk of cardiovascular disease in a subgroup of middle-aged individuals with both diabetes mellitus and the haptoglobin 2-2 genotype.对于同时患有糖尿病和触珠蛋白2-2基因型的中年亚组人群,他汀类药物与抗氧化剂联合治疗在降低心血管疾病风险方面优于单独使用他汀类药物。
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Pharmacogenomics in prevention of diabetic cardiovascular disease: utilization of the haptoglobin genotype in determining benefit from vitamin E.药物基因组学在预防糖尿病心血管疾病中的应用:利用触珠蛋白基因型确定维生素E的获益情况。
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Vitamin E supplementation reduces cardiovascular events in a subgroup of middle-aged individuals with both type 2 diabetes mellitus and the haptoglobin 2-2 genotype: a prospective double-blinded clinical trial.补充维生素E可降低患有2型糖尿病且触珠蛋白2-2基因型的中年亚组人群的心血管事件发生率:一项前瞻性双盲临床试验。
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5
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引用本文的文献

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Curr Diab Rep. 2015 Mar;15(3):9. doi: 10.1007/s11892-015-0579-4.
2
Type 1 diabetes mellitus and cardiovascular disease: a scientific statement from the American Heart Association and American Diabetes Association.1型糖尿病与心血管疾病:美国心脏协会和美国糖尿病协会的科学声明
Diabetes Care. 2014 Oct;37(10):2843-63. doi: 10.2337/dc14-1720. Epub 2014 Aug 11.
3
The role of oxidized low-density lipoproteins in atherosclerosis: the myths and the facts.氧化型低密度脂蛋白在动脉粥样硬化中的作用:神话与事实。
Mediators Inflamm. 2013;2013:714653. doi: 10.1155/2013/714653. Epub 2013 Oct 3.
4
Haptoglobin phenotype, pre-eclampsia, and response to supplementation with vitamins C and E in pregnant women with type-1 diabetes.结合珠蛋白表型、子痫前期与 1 型糖尿病孕妇补充维生素 C 和 E 的反应。
BJOG. 2013 Sep;120(10):1192-9. doi: 10.1111/1471-0528.12288. Epub 2013 May 30.
5
Haptoglobin phenotype, preeclampsia risk and the efficacy of vitamin C and E supplementation to prevent preeclampsia in a racially diverse population.触珠蛋白表型、子痫前期风险以及维生素 C 和 E 补充剂预防不同种族人群子痫前期的疗效。
PLoS One. 2013;8(4):e60479. doi: 10.1371/journal.pone.0060479. Epub 2013 Apr 3.
6
Patient selection and vitamin E treatment in diabetes mellitus.糖尿病患者的选择与维生素E治疗
Expert Rev Cardiovasc Ther. 2013 Mar;11(3):319-26. doi: 10.1586/erc.12.187.
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Haptoglobin genotype and its role in diabetic cardiovascular disease.触珠蛋白基因型及其在糖尿病心血管疾病中的作用。
J Cardiovasc Transl Res. 2012 Aug;5(4):423-35. doi: 10.1007/s12265-012-9361-z. Epub 2012 Mar 24.
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Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases.抗氧化剂补充剂对健康参与者及各类疾病患者死亡率的预防作用
Cochrane Database Syst Rev. 2012 Mar 14;2012(3):CD007176. doi: 10.1002/14651858.CD007176.pub2.
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Cardiovascular disease in diabetes.糖尿病中的心血管疾病
Diabetes Care. 2010 Apr;33(4):e49-54. doi: 10.2337/dc10-zb04.
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HDL as a biomarker, potential therapeutic target, and therapy.高密度脂蛋白作为一种生物标志物、潜在治疗靶点及治疗手段。
Diabetes. 2009 Dec;58(12):2711-7. doi: 10.2337/db09-0538.