血管内皮生长因子936 C/T多态性与口腔鳞状细胞癌的血管侵犯相关。
Vascular endothelial growth factor 936 C/T polymorphism is associated with vascular invasion in oral squamous cell carcinoma.
作者信息
Cheng Chieh-Yuan, Chang Che-Shoa, Liu Chung-Ji, Kao Shou-Yen
机构信息
Department of Oral and Maxillofacial Surgery, Mackay Memorial Hospital, Taipei, Taiwan.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Jul;106(1):79-84. doi: 10.1016/j.tripleo.2007.10.009. Epub 2008 Mar 4.
OBJECTIVE
The objective of this study was to analyze the relation of VEGF 936 C/T polymorphisms in progression of oral squamous cell carcinoma (OSCC) patients and healthy subjects in Taiwan.
STUDY DESIGN
We genotyped 218 patients with OSCC, comparing the genotypes and gene frequencies with those of 121 control subjects. VEGF 936 C/T polymorphisms were determined by using polymerase chain reaction and restriction fragment length polymorphism.
RESULTS
There were no significant differences in genotype, phenotype, or gene frequency between the OSCC and control groups. Among patients with OSCC, there were also no significant differences in the polymorphism between those with and without cervical lymph node metastases or in survival. However, 21 of the 218 patients had vascular invasion by their OSCC, and these patients were significantly more likely to have a C/C (P = .033) or C/T genotype (P = .026) than were those without vascular invasion.
CONCLUSIONS
This study suggests that the VEGF 936 C allele is associated with vascular invasion in OSCC.
目的
本研究旨在分析台湾口腔鳞状细胞癌（OSCC）患者和健康受试者中VEGF 936 C/T基因多态性与疾病进展的关系。
研究设计
我们对218例OSCC患者进行基因分型，并将其基因型和基因频率与121例对照受试者进行比较。采用聚合酶链反应和限制性片段长度多态性方法测定VEGF 936 C/T基因多态性。
结果
OSCC组与对照组在基因型、表型或基因频率方面无显著差异。在OSCC患者中，有或无颈部淋巴结转移患者的多态性或生存率也无显著差异。然而，218例患者中有21例发生了OSCC血管侵犯，这些患者比无血管侵犯的患者更有可能具有C/C基因型（P = .033）或C/T基因型（P = .026）。
结论
本研究提示VEGF 936 C等位基因与OSCC血管侵犯有关。
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