Oral and Maxillofacial Surgery Laboratory, Department of Stomatology, School of Stomatology, Taihe Hospital, Hubei University of Medicine, 32 South Renmin Road, Shiyan, 442000, Hubei Province, People's Republic of China.
Mol Biol Rep. 2013 Oct;40(10):5987-92. doi: 10.1007/s11033-013-2708-y. Epub 2013 Sep 21.
The association between vascular endothelial growth factor (VEGF) gene polymorphisms and risk of head and neck cancer (HNC) were investigated in many published studies; however, the currently available results are inconclusive. Therefore, we conducted this meta-analysis for deriving a more precise estimation of association between VEGF polymorphisms and the risk of HNC. Finally, we yield eight case-control studies involving six polymorphisms contain 2,444 individuals from PubMed, Embase, and CNKI up to January 30, 2013 (last updated on May 4, 2013). The results of meta-analysis showed that all the six polymorphisms of VEGF were not associated with risk of HNC [OR 1.25, 95 % CI (0.60-1.58) for TT vs. CC for 936 C/T; OR 1.41, 95 % CI (0.79-2.52) for GG vs. AA for -1,154 A/G; OR 0.97, 95 % CI (0.38-2.50) for CC vs. GG for 405 G/C; OR 1.44, 95 % CI (0.80-2.61) for AA vs. CC for 2,578 C/A; OR 1.27, 95 % CI (0.77-3.72) for TT vs. CC for -460 C/T; and OR 0.87, 95 % CI (0.37-2.06) for GG vs. CC for -634 G/C]. When performed subgroup analysis according to ethnicity for VEGF 936 C/T, the results suggested that it was not associated with the risk of HNC for either Asians [OR 0.84, 95 % CI (0.27-2.56) for TT vs. CC] or Caucasians [OR 2.10, 95 % CI (0.82-5.37) for TT vs. CC]. However, due to the limitations of this meta-analysis, more well designed, larger sample size, and adjusted risk factors studies are suggested to further assess the findings.
血管内皮生长因子（VEGF）基因多态性与头颈部癌症（HNC）风险之间的关联已在许多已发表的研究中进行了探讨；然而，目前的研究结果尚无定论。因此，我们进行了这项荟萃分析，以更准确地评估 VEGF 多态性与 HNC 风险之间的关联。最终，我们从 PubMed、Embase 和中国知网（CNKI）中获取了截至 2013 年 1 月 30 日（最后更新于 2013 年 5 月 4 日）的八项病例对照研究，共包含 2444 名个体，涉及 VEGF 的六个多态性。荟萃分析的结果表明，VEGF 的所有六个多态性均与 HNC 风险无关[936C/T 的 TT 对 CC 的比值比（OR）为 1.25，95%可信区间（CI）为（0.60-1.58）；-1,154A/G 的 GG 对 AA 的 OR 为 1.41，95%CI 为（0.79-2.52）；405G/C 的 CC 对 GG 的 OR 为 0.97，95%CI 为（0.38-2.50）；2,578C/A 的 AA 对 CC 的 OR 为 1.44，95%CI 为（0.80-2.61）；-460C/T 的 TT 对 CC 的 OR 为 1.27，95%CI 为（0.77-3.72）；-634G/C 的 GG 对 CC 的 OR 为 0.87，95%CI 为（0.37-2.06）]。当根据 VEGF936C/T 的种族进行亚组分析时，结果表明其与 HNC 风险无关，无论是亚洲人[OR 0.84，95%CI 为（0.27-2.56）的 TT 对 CC]还是高加索人[OR 2.10，95%CI 为（0.82-5.37）的 TT 对 CC]。然而，由于本荟萃分析的局限性，建议进行更多设计良好、样本量更大且调整了风险因素的研究，以进一步评估这些发现。
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