一组自由生活的健康老年人的营养状况、抗氧化/促氧化平衡与认知能力之间的关系。

Relationship among nutritional status, pro/antioxidant balance and cognitive performance in a group of free-living healthy elderly.

作者信息

Rondanelli M, Trotti R, Opizzi A, Solerte S B

机构信息

Department of Applied Health Sciences, Section of Human Nutrition and Dietetics, Faculty of Medicine, University of Pavia, Personal Health Care Centre of Pavia, Pavia, Italy.

出版信息

Minerva Med. 2007 Dec;98(6):639-45.

PMID:18299677

Abstract

AIM

Nutrition plays a role in health promotion and well-being, but there is still a lack of knowledge about nutrition-related risk factors in aging cognitive impairment. The purpose of this project was to evaluate the link between nutritional status, cognitive performance and pro/antioxidant balance in healthy elderly subjects residing in a small metropolitan community.

METHODS

The subjects were 69 free-living urban healthy elderly people (41 females and 28 males aged 84+/-7 years, mean +/- standard deviation SD, range 70-89). In this group of elderly subjects an analysis of the diet over the 3 days before the study entry was performed. The nutrients intake for individuals were compared with the Italian Recommended Dietary Allowances (RDA). We also collected residents' background information, nutritional status (Mini Nutritional Assessment, MNA), and data on daily nursing routines in institutions, including nutritional care. Plasma malondialdehyde and erythrocyte glutathione peroxidase activity were evaluated in elderly people as compared to a group of healthy young people (control group) as indices of the oxidative balance.

RESULTS

The mean vitamin and mineral intake for participants met the RDAs except for calcium and vitamin D. No difference was observed as regards plasma malondialdehyde between young and elderly subjects: 4.5 (3-6.2) mmol/L vs 4.45 (2.4-5.8) mmol/L respectively, median with range, whereas the latter exhibited higher erythrocyte glutathione peroxidase activity: 16.0 (9.3-48) U/g hemoglobin (Hb) vs 15 (10-35) U/g Hb, respectively, median with range (P<0.05). A significant negative correlation (P<0.05, r=0.24) between dietary intake of vitamin D and malondialdeyde and between dietary intake of vitamin D and poor performance on cognitive tests (P<0.01, r=0.35) was observed.

CONCLUSION

In line with previous findings, our results highlighted the potential impact of nutritional factors on cognitive performance in older adults.

摘要

目的

营养在促进健康和幸福方面发挥着作用，但对于衰老认知障碍中与营养相关的风险因素仍缺乏了解。本项目的目的是评估居住在一个小型都市社区的健康老年人的营养状况、认知表现和促氧化/抗氧化平衡之间的联系。

方法

研究对象为69名自由生活的城市健康老年人（41名女性和28名男性，年龄84±7岁，平均±标准差SD，范围70 - 89岁）。在这组老年受试者中，对研究入组前3天的饮食进行了分析。将个体的营养素摄入量与意大利推荐膳食摄入量（RDA）进行比较。我们还收集了居民的背景信息、营养状况（微型营养评定法，MNA）以及机构日常护理数据，包括营养护理。与一组健康年轻人（对照组）相比，评估了老年人血浆丙二醛和红细胞谷胱甘肽过氧化物酶活性，作为氧化平衡的指标。

结果

除钙和维生素D外，参与者的平均维生素和矿物质摄入量符合RDA。青年和老年受试者的血浆丙二醛未观察到差异：分别为4.5（3 - 6.2）mmol/L和4.45（2.4 - 5.8）mmol/L，中位数及范围，而后者红细胞谷胱甘肽过氧化物酶活性较高：分别为16.0（9.3 - 48）U/g血红蛋白（Hb）和15（10 - 35）U/g Hb，中位数及范围（P<0.05）。观察到维生素D的膳食摄入量与丙二醛之间以及维生素D的膳食摄入量与认知测试表现不佳之间存在显著负相关（P<0.05，r = 0.24；P<0.01，r = 0.35）。