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骨质疏松性椎体骨折再探讨

Osteoporotic vertebral fractures redux.

作者信息

Lentle B C, Gordon P, Ward L

机构信息

BC Women's Hospital and Health Sciences Centre, Vancouver, BC, Canada.

出版信息

Minerva Med. 2008 Feb;99(1):73-89.

Abstract

Osteoporosis remains an important cause of morbidity and mortality especially in the elderly. This fact is largely due to fractures of the proximal femur and spine. As recently recognized, vertebral fractures are as much a threat to health and longevity as fractures of the proximal femur. In recent decades, the development of tools to evaluate fracture risk as well as medications to treat osteoporosis has altered the management of people who are at fracture risk. At the same time identification and management procedures concerning spinal fracturing are not very clear. Besides there is not even clear consensus about what exactly constitutes a vertebral fracture, particularly those of minor degree. While height loss is a simple and valuable tool to detect vertebral fractures, it is neither sensitive nor specific enough to replace radiographs. Some 65% of fractures cause no symptoms. Often vertebral fractures are misdiagnosed, especially if they have occurred silently and if the opportunity for diagnosis arises fortuitously. It is to the patient's benefit that radiologists report and physicians identify vertebral fractures evident on a chest or other radiograph, no matter how incidental to the immediate clinical indication for the examination. Technological evolution now allows dual-energy x-ray absorptiometry machines to be used to take spine images while doing a densitometry. The images are adequate, even if not of high radiographic quality, and, more important, the patient undergoes a smaller radiation dose than with conventional spinal radiographs. Such technology may promote fracture recognition. The recognition of vertebral fractures, as well as the prevention and treatment of further fractures, will likely do much to reduce both the burden of osteoporosis-related morbidity and mortality, as well as fracture-related costs to healthcare systems.

摘要

骨质疏松症仍然是发病和死亡的一个重要原因,尤其是在老年人中。这一事实很大程度上归因于股骨近端和脊柱骨折。最近认识到,椎体骨折对健康和寿命的威胁与股骨近端骨折一样大。近几十年来,评估骨折风险的工具以及治疗骨质疏松症的药物的发展改变了对有骨折风险人群的管理。与此同时,关于脊柱骨折的识别和管理程序并不十分明确。此外,对于究竟什么构成椎体骨折,尤其是轻度骨折,甚至没有明确的共识。虽然身高降低是检测椎体骨折的一种简单而有价值的工具,但它既不够敏感也不够特异,无法替代X光片。约65%的骨折没有症状。椎体骨折常常被误诊,尤其是如果它们是悄然发生的,而且诊断机会是偶然出现的。放射科医生报告、医生识别胸部或其他X光片上明显的椎体骨折,无论其与检查的直接临床指征多么不相关,这对患者是有益的。技术的发展现在允许在进行骨密度测量时使用双能X线吸收仪拍摄脊柱图像。这些图像是足够的,即使不是高质量的X光片,更重要的是,与传统脊柱X光片相比,患者接受的辐射剂量更小。这样的技术可能会促进骨折的识别。椎体骨折的识别以及进一步骨折的预防和治疗,可能在很大程度上减轻骨质疏松症相关的发病和死亡负担,以及医疗保健系统与骨折相关的费用。

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