Faris Mary
Department of Drug Discovery, MannKind Corporation, Valencia, California 91355, USA.
Int Rev Immunol. 2008 Jan-Apr;27(1-2):71-8. doi: 10.1080/08830180701777475.
Adult T-cell leukemia/lymphoma is an aggressive lymphoproliferative disorder of CD4+ T lymphocytes associated with human T-cell leukemia virus type 1 (HTLV-I) infection. Approximately 5% of infected people will develop an aggressive form of ATL, characterized by high circulating cell count, skin and organ infiltration and expression of cytokine, chemokine and survival genes. The available therapies for ATL have minimal efficacy, with few responders and poor survival. Recent advances have led to the identification of key molecules and cellular pathways involved in HTLV-1 mediated cellular transformation and tumor progression. We describe within a few key elements that contribute to neoplastic development of ATL, in addition to interesting molecular drug targets that may lead to more effective therapeutic strategies.
成人T细胞白血病/淋巴瘤是一种侵袭性的CD4 + T淋巴细胞淋巴增殖性疾病，与1型人类T细胞白血病病毒（HTLV-I）感染相关。大约5%的感染者会发展为侵袭性ATL，其特征为循环细胞计数高、皮肤和器官浸润以及细胞因子、趋化因子和生存基因的表达。现有的ATL治疗方法疗效甚微，应答者寥寥，生存率低。最近的进展已导致鉴定出参与HTLV-1介导的细胞转化和肿瘤进展的关键分子和细胞途径。除了可能导致更有效治疗策略的有趣分子药物靶点外，我们还描述了促成ATL肿瘤发生的几个关键因素。
