Cawthon Peggy Mannen, Fullman Robin L, Marshall Lynn, Mackey Dawn C, Fink Howard A, Cauley Jane A, Cummings Steven R, Orwoll Eric S, Ensrud Kristine E
Research Institute, California Pacific Medical Center, San Francisco, California 94107-1762, USA.
J Bone Miner Res. 2008 Jul;23(7):1037-44. doi: 10.1359/jbmr.080227.
The aim of these analyses was to describe the association between physical performance and risk of hip fractures in older men. Performance on five physical function exams (leg power, grip strength, usual walking pace, narrow walk balance test, and five repeated chair stands) was assessed in 5902 men >or=65 yr of age. Performance (time to complete or strength) was analyzed as quartiles, with an additional category for unable to complete the measure, in proportional hazards models. Follow-up averaged 5.3 yr; 77 incident hip fractures were confirmed by physician review of radiology reports. Poor physical performance was associated with an increased risk of hip fracture. In particular, repeated chair stand performance was strongly related to hip fracture risk. Men unable to complete this exam were much more likely to experience a hip fracture than men in the fastest quartile of this test (multivariate hazard ratio [MHR]: 8.15; 95% CI: 2.65, 25.03). Men with the worst performance (weakest/slowest quartile or unable) on at least three exams had an increased risk of hip fracture compared with men with higher functioning (MHR: 3.14, 95% CI: 1.46, 6.73). Nearly two thirds of the hip fractures (N = 49, 64%) occurred in men with poor performance on at least three exams. Poor physical function is independently associated with an increased risk of hip fracture in older men. The repeated chair stands exam should be considered in clinical settings for evaluation of hip fracture risk. Concurrent poor performance on multiple physical function exams is associated with an increased risk of hip fractures.
这些分析的目的是描述老年男性身体机能与髋部骨折风险之间的关联。对5902名年龄≥65岁的男性进行了五项身体机能测试(腿部力量、握力、平常步行速度、窄道步行平衡测试以及五次重复起坐测试)。在比例风险模型中,将测试表现(完成时间或力量)分析为四分位数,并为无法完成测试的情况增设一个类别。随访平均时长为5.3年;经医生查阅放射学报告确认有77例髋部骨折病例。身体机能较差与髋部骨折风险增加相关。特别是,重复起坐测试表现与髋部骨折风险密切相关。无法完成该测试的男性比在该测试中处于最快四分位数的男性发生髋部骨折的可能性要高得多(多变量风险比[MHR]:8.15;95%置信区间:2.65,25.03)。与机能较好的男性相比,至少三项测试表现最差(最弱/最慢四分位数或无法完成测试)的男性发生髋部骨折的风险增加(MHR:3.14,95%置信区间:1.46,6.73)。近三分之二(N = 49,64%)的髋部骨折发生在至少三项测试表现较差的男性中。身体机能差独立地与老年男性髋部骨折风险增加相关。在临床环境中评估髋部骨折风险时应考虑重复起坐测试。多项身体机能测试同时表现较差与髋部骨折风险增加相关。