Healey Paul R, Mitchell Paul
Department of Ophthalmology, University of Sydney, Centre for Vision Research, Westmead Millennium Institute, Westmead Hospital, Australia.
J Glaucoma. 2008 Jan-Feb;17(1):11-4. doi: 10.1097/IJG.0b013e318133fc34.
To determine prevalence and associations of pits of the optic disc in an older population and assess their relationship to open-angle glaucoma.
Population-based cross-sectional study.
The Blue Mountains Eye Study examined 3654 persons (82.4% of permanent residents) aged over 48 years. Stereo-optic disc photographs were graded in a masked fashion.
Nine pits were found in 7 persons, a population prevalence of 0.19%. Three morphologic subtypes were found. Four peripheral pits were found at the inferior pole. Four central pits were located adjacent to the main vessel trunk. One pit was on the temporal disc margin. Pit prevalence increased with age (beta=0.0879, P=0.0099). It was strongly associated with high-pressure open-angle glaucoma [odds ratio (OR) 29, 95% confidence interval (95CI) 7-127], beta-peripapillary atrophy (OR 7.5, 95CI 2-32), and optic disc hemorrhage (OR 42, 95CI 9-183) after adjusting for age and sex. All peripheral pits were associated with paracentral visual field loss.
The classically described temporal optic disc pit was the rarest morphologic subtype found in this older population. Optic disc pits were primarily associated with glaucoma and the related signs of optic disc hemorrhage and beta-peripapillary atrophy. The previously reported optic disc pit association with low-tension glaucoma may represent acquisition bias.
确定老年人群视盘凹陷的患病率及相关性，并评估其与开角型青光眼的关系。
基于人群的横断面研究。
蓝山眼研究对3654名年龄在48岁以上的人（占常住人口的82.4%）进行了检查。立体视盘照片采用盲法分级。
在7个人中发现了9个视盘凹陷，人群患病率为0.19%。发现了三种形态学亚型。在下极发现了4个周边凹陷。4个中央凹陷位于主要血管主干附近。1个凹陷位于颞侧视盘边缘。视盘凹陷患病率随年龄增加而升高（β=0.0879，P=0.0099）。在对年龄和性别进行校正后，其与高眼压性开角型青光眼[比值比（OR）29，95%置信区间（95CI）7-127]、β-视盘周围萎缩（OR 7.5，95CI 2-32）以及视盘出血（OR 42，95CI 9-183）密切相关。所有周边凹陷均与旁中心视野缺损有关。
经典描述的颞侧视盘凹陷是该老年人群中最罕见的形态学亚型。视盘凹陷主要与青光眼以及视盘出血和β-视盘周围萎缩等相关体征有关。先前报道的视盘凹陷与低眼压性青光眼的关联可能存在获得性偏倚。
