Ver Hoef Lawrence W, Sawrie Stephen, Killen Jeff, Knowlton Robert C
University of Alabama Epilepsy Center, Department of Neurology, Birmingham, Alabama, USA.
J Clin Neurophysiol. 2008 Feb;25(1):1-6. doi: 10.1097/WNP.0b013e318163a6c0.
The purpose of this study is to examine the pattern of mesial temporal lobe activity in patients with left mesial temporal sclerosis (LMTS) and normal control subjects during a verbal memory task using magnetoencephalography. Six LMTS patients and seven normal control subjects performed a word recognition task while event-related neuromagnetic responses were recorded for 248 trials in each of two runs. An equivalent current dipole model was used to localize activity sources and determine if the right or left mesial temporal lobe was active. All six (100%) LMTS patients but only two (28%) normal control subjects had right mesial temporal activity (P < 0.02). Two (33%) LMTS patients and 6 (86%) normal control subjects had left mesial temporal activity (P = 0.27). No significant differences in latency or duration of activity were seen between left and right sides or between groups. Our data suggest that patients with left hippocampal dysfunction are more likely to recruit the right mesial temporal lobe during verbal memory tasks than normal control subjects. A trend toward less left mesial temporal activity in LMTS patients is seen as well. Further study is needed to determine the predictive value of this technique regarding postresection memory outcome.
本研究的目的是使用脑磁图检查左侧颞叶内侧硬化（LMTS）患者和正常对照者在言语记忆任务期间颞叶内侧的活动模式。6名LMTS患者和7名正常对照者进行了单词识别任务，同时在两次测试的每次248次试验中记录事件相关神经磁反应。使用等效电流偶极子模型定位活动源，并确定右侧或左侧颞叶内侧是否活跃。所有6名（100%）LMTS患者但只有2名（28%）正常对照者出现右侧颞叶内侧活动（P < 0.02）。2名（33%）LMTS患者和6名（86%）正常对照者出现左侧颞叶内侧活动（P = 0.27）。左右两侧或两组之间在活动潜伏期或持续时间上没有显著差异。我们的数据表明，与正常对照者相比，左侧海马功能障碍患者在言语记忆任务期间更有可能动用右侧颞叶内侧。在LMTS患者中也观察到左侧颞叶内侧活动减少的趋势。需要进一步研究以确定该技术对切除术后记忆结果的预测价值。
