MEG Center Dr. Pérez Modrego, Complutense University of Madrid, Madrid, Spain.
Epilepsy Behav. 2009 Nov;16(3):527-33. doi: 10.1016/j.yebeh.2009.09.007. Epub 2009 Oct 8.
The risk of cognitive decline after mesial temporal lobe (MTL) resection in the dominant hemisphere for treatment of epilepsy has been assessed with the intracarotid amytal procedure and functional neuroimaging. In this study we used magnetoencephalography (MEG) to analyze memory profiles in patients with left hippocampal sclerosis (HS). Biomagnetic brain activity related to successful memory was compared in nine patients with left HS and nine age-matched controls. Patients manifested a higher number of activity sources over the right inferior parietal lobe in the late portion of the time window, and higher activity in the right than in the left MTL between 400 and 800 ms. This was reinforced by a -0.46 MTL laterality index, which indicates right MTL dominance. Controls showed a higher number of dipoles in the left anterior ventral prefrontal region, between 400 and 600 ms, and in the left MTL across the whole time window. Three patients who underwent a left temporal lobectomy, were seizure free, and who did not exhibit memory impairment after left temporal lobectomy, showed no activity in the left MTL presurgically. These results could support the ability of MEG to describe the time-modulated brain activity related to memory success in patients with epilepsy with left HS.
内侧颞叶（MTL）切除术治疗优势半球癫痫后认知下降的风险已通过颈动脉内戊巴比妥试验和功能神经影像学进行评估。在这项研究中，我们使用脑磁图（MEG）分析左侧海马硬化（HS）患者的记忆特征。在 9 名左侧 HS 患者和 9 名年龄匹配的对照组中比较了与成功记忆相关的生物磁脑活动。患者在时间窗的晚期显示出更多的右下顶叶的活性源，并且在 400 到 800 毫秒之间，右侧的活动高于左侧的 MTL。这被 0.46 的 MTL 侧化指数所加强，表明右侧 MTL 优势。对照组在 400 到 600 毫秒之间的左侧前腹侧前额叶区域和整个时间窗的左侧 MTL 中显示出更多的偶极子。3 名患者接受了左侧颞叶切除术，术后无癫痫发作，且左侧颞叶切除后无记忆障碍，术前左侧 MTL 无活动。这些结果可能支持 MEG 描述与左侧 HS 癫痫患者记忆成功相关的时间调制脑活动的能力。
