脂肪酶-钌组合对1,2-二芳基乙醇的高度对映选择性动态动力学拆分

Highly enantioselective dynamic kinetic resolution of 1,2-diarylethanols by a lipase-ruthenium couple.

作者信息

Kim Mahn-Joo, Choi Yoon Kyung, Kim Sol, Kim Daeho, Han Kiwon, Ko Soo-Byung, Park Jaiwook

机构信息

Department of Chemistry, Pohang University of Science and Technology (POSTECH), San-31 Hyojadong, Pohang 790-784, Korea.

出版信息

Org Lett. 2008 Mar 20;10(6):1295-8. doi: 10.1021/ol800163z. Epub 2008 Feb 28.

DOI:10.1021/ol800163z

PMID:18303906

Abstract

A practical procedure has been developed for the dynamic kinetic resolution of 1,2-diarylethanols. This procedure employs a highly enantioselective lipase from Pseudomonas stutzeri (trade name, lipase TL) as the resolution catalyst and a ruthenium complex as the racemization catalyst. Sixteen 1,2-diarylethanols have been efficiently resolved to provide their acetyl derivatives with good yields (95-97%) and high enantiomeric excesses (96-99%).

摘要

已开发出一种用于1,2 - 二芳基乙醇动态动力学拆分的实用方法。该方法使用来自施氏假单胞菌的一种高度对映选择性脂肪酶（商品名，脂肪酶TL）作为拆分催化剂，以及一种钌配合物作为外消旋化催化剂。十六种1,2 - 二芳基乙醇已被有效拆分，以良好的产率（95 - 97%）和高对映体过量（96 - 99%）得到它们的乙酰基衍生物。