使用可循环钯纳米催化剂对伯胺进行动态动力学拆分以实现外消旋化
Dynamic kinetic resolution of primary amines with a recyclable Pd nanocatalyst for racemization.
作者信息
Kim Mahn-Joo, Kim Won-Hee, Han Kiwon, Choi Yoon Kyung, Park Jaiwook
机构信息
Department of Chemistry, Pohang University of Science and Technology, San-31, Hyojadong, Pohang 790-784, Korea.
出版信息
Org Lett. 2007 Mar 15;9(6):1157-9. doi: 10.1021/ol070130d. Epub 2007 Feb 10.
A practical procedure for the dynamic kinetic resolution (DKR) of primary amines has been developed. This procedure employs a palladium nanocatalyst as the racemization catalyst, a commercial lipase (Novozym-435) as the resolution catalyst, and ethyl acetate or ethyl methoxyacetate as the acyl donor. Eleven primary amines and one amino acid amide have been efficiently resolved with good yields (85-99%) and high enantiomeric excesses (97-99%). [reaction: see text]
已开发出一种用于伯胺动态动力学拆分（DKR）的实用方法。该方法使用钯纳米催化剂作为外消旋化催化剂，商业脂肪酶（诺维信-435）作为拆分催化剂，乙酸乙酯或甲氧基乙酸乙酯作为酰基供体。十一种伯胺和一种氨基酸酰胺已被有效拆分，产率良好（85-99%），对映体过量值高（97-99%）。[反应：见正文]
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