Blokh K O, Poltorak V V, Blokh O V
Vopr Med Khim. 1991 Jan-Feb;37(1):42-3.
Single administration of streptozotocin at a dose of 200 mg/kg into mice males of the C57BL/KsJY db/m strain induced severe form of insulin-dependent diabetes within the earlier periods as compared with fractional injection of the drug (40 mg/kg daily within 5 days). Streptozotocin-induced diabetes, developed after single administration of the drug, caused pronounced destructions in lymphoid tissue, primarily in thymus as content of DNA was drastically decreased in the tissue and level of DNA breakdown products was increased. The lympholytic effect of streptozotocin was less distinct after fractional administration.
与分次注射链脲佐菌素（5天内每天40mg/kg）相比，以200mg/kg的剂量对C57BL/KsJY db/m品系雄性小鼠单次注射链脲佐菌素，在早期就诱发了严重形式的胰岛素依赖型糖尿病。单次给药后发生的链脲佐菌素诱导的糖尿病导致淋巴组织明显破坏，主要是胸腺，因为组织中的DNA含量急剧下降，DNA分解产物水平升高。分次给药后链脲佐菌素的淋巴细胞溶解作用不太明显。
