生理条件下凋亡和坏死性细胞死亡的作用。

Role of apoptotic and necrotic cell death under physiologic conditions.

作者信息

Han Song Iy, Kim Yong-Seok, Kim Tae-Hyoung

机构信息

Research Center for Resistant Cells, Chosun University School of Medicine, Gwangju, Korea.

出版信息

BMB Rep. 2008 Jan 31;41(1):1-10. doi: 10.5483/bmbrep.2008.41.1.001.

DOI:10.5483/bmbrep.2008.41.1.001

PMID:18304444

Abstract

Apoptosis is considered to be a programmed and controlled mode of cell death, whereas necrosis has long been described as uncontrolled and accidental cell death resulting from extremely harsh conditions. In the following review, we will discuss the features and physiological meanings as well as recent advances in the elucidation of the signaling pathways of both apoptotic cell death and programmed necrotic cell death.

摘要

细胞凋亡被认为是一种程序性且受调控的细胞死亡方式，而坏死长期以来被描述为因极端恶劣条件导致的不受控制的意外细胞死亡。在接下来的综述中，我们将讨论凋亡性细胞死亡和程序性坏死性细胞死亡的特征、生理意义以及在阐明其信号通路方面的最新进展。