Letoublon R, Merit X, Frot-Coutaz J
Laboratoire de Biochimie des Membranes (LBTM-CNRS UM 380024) Université Claude Bernard Lyon 1, Villeurbanne, France.
Biochem Int. 1991 Jan;23(2):221-30.
In this report, we describe the main characteristics of the transfer of N-acetylglucosamine within the nucleus of rat hepatocytes. The glycosylation pathway includes the presence of lipids which mediate the nuclear proteins glycosylation. The level of dolichylphosphate seems low and thus could be a regulation factor in the nuclear glycosylations. The discussion deals with the membranous character of the acceptors and the N-acetylglucosaminyltransferase, the N-linkage of the sugar moiety to nuclear proteins and the function of such glycosylation.
在本报告中，我们描述了大鼠肝细胞细胞核内N-乙酰葡糖胺转移的主要特征。糖基化途径包括介导核蛋白糖基化的脂质的存在。磷酸多萜醇的水平似乎较低，因此可能是核糖基化的一个调节因子。讨论涉及受体和N-乙酰葡糖胺转移酶的膜性特征、糖部分与核蛋白的N-连接以及这种糖基化的功能。
