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Pharmacokinetic studies of hematoporphyrin derivatives on rat hepatocytes. Protoporphyrin dimethyl ester hematoporphyrin ether versus dihematoporphyrin ether-free hematoporphyrin derivative.

作者信息

Both P, Häberlein H, Gressner A M, Sieg I, Doss M O

机构信息

Abteilung für Klinische Biochemie im Fachbereich Humanmedizin, Universität Marburg.

出版信息

Biol Chem Hoppe Seyler. 1991 Feb;372(2):69-73. doi: 10.1515/bchm3.1991.372.1.69.

DOI:10.1515/bchm3.1991.372.1.69
PMID:1830485
Abstract

Rat liver cells incorporate monomeric as well as dimeric hematoporphyrin derivatives. Time-dependent incubation assays gave evidence that monomeric compounds are more efficiently incorporated compared to protoporphyrin dimethyl ester hematoporphyrin ether. HL60 cells take up dimeric porphyrins in substantially higher quantities than hepatocytes do. These results allow the conclusion that physiological versus tumor cells behave differently with respect to porphyrin uptake: Whereas physiological cells prefer monomeric porphyrins, tumor cells preferentially incorporate dimeric porphyrins.

摘要

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