Hemachandran Manikkapurath, Rajwanshi Arvind, Srinivasan Radhika, Nijhawan Raje, Radotra Bishan Dass
Department of Cytology, Postgraduate Institute of Medical Education and Research, Chandigarh.
Indian J Pathol Microbiol. 2007 Oct;50(4):859-61.
Hürthle cell neoplasms (HCN) are an uncommon group of tumors of the thyroid gland. Fine needle aspiration cytology (FNAC) is an important diagnostic tool in solitary nodules of the thyroid gland. A 5-year retrospective analysis of all cases diagnosed as HCN on cytology was performed and correlated with the corresponding histopathology wherever available. There were 13 cases diagnosed as HCN out of which 6 cases had subsequent histopathologic examination. Four were adenomas and two were carcinomas. In addition, 3 cases that were adenomas on histopathology were reported on cytology as colloid goiter with cystic degeneration in 2 cases and as follicular adenoma in 1 case. There was extensive cystic degeneration in the former two cases whereas poor cellular preservation led to misdiagnosis in the third case. There were no specific cytomorphological features that distinguished adenoma from carcinoma. FNAC has a high specificity for a diagnosis of HCN, but the sensitivity is not as high because of sampling error.
许特莱细胞肿瘤（HCN）是一组不常见的甲状腺肿瘤。细针穿刺细胞学检查（FNAC）是甲状腺单发结节的重要诊断工具。对所有经细胞学诊断为HCN的病例进行了为期5年的回顾性分析，并在可能的情况下与相应的组织病理学结果进行了关联。共有13例被诊断为HCN，其中6例随后进行了组织病理学检查。4例为腺瘤，2例为癌。此外，组织病理学诊断为腺瘤的3例病例，细胞学报告2例为伴有囊性变的胶样甲状腺肿，1例为滤泡性腺瘤。前两例有广泛的囊性变，而第三例因细胞保存不佳导致误诊。腺瘤和癌之间没有可区分的特异性细胞形态学特征。FNAC对HCN的诊断具有较高的特异性，但由于采样误差，敏感性不高。
