Del Nero A, Mandressi A, Longo G, Cogni M, Mangiarotti B, Buzzetti V, Russo R
Istituto di Urologia, Università di Milano.
Arch Ital Urol Nefrol Androl. 1991 Jun;63(2):249-51.
The authors treated 10 advanced renal cell carcinoma with circadian venous continuous infusion of 5-Fluoro 2-Deoxyuridine (FUDR). The drug was delivered by Medtronic Synchromed implantable pump in 14-day cycles alternating with 14-day intervals of physiologic saline infusion. Of the patient observed for at least 8 months (range: 8-32, median: 22.1) 1 showed progression. Circadian continuous central venous infusion of FUDR is minimally toxic. The FUDR can be delivered safely and conveniently in this way for long spans. This therapy is administrated in on entirely out patient setting, and associated with a normal quality of life.
作者采用昼夜静脉持续输注5-氟-2-脱氧尿苷（FUDR）治疗10例晚期肾细胞癌。药物通过美敦力Synchromed植入式泵以14天为周期给药，与14天的生理盐水输注间隔交替进行。在观察至少8个月（范围：8 - 32个月，中位数：22.1个月）的患者中，1例出现病情进展。昼夜持续中心静脉输注FUDR的毒性极小。通过这种方式可以安全、方便地长期给予FUDR。该治疗完全在门诊进行，且与正常生活质量相关。
