Bingener Juliane, Cox Diane, Michalek Joel, Mejia Alejandro
Department of Surgery, University of Texas Health Science Center at San Antonio, Texas 78229, USA.
Am Surg. 2008 Feb;74(2):156-9.
The Model for End Stage Liver Disease (MELD) score is a mortality predictor in patients awaiting liver transplantation. We evaluated the MELD score's ability to predict morbidity for patients with cirrhosis undergoing laparoscopic cholecystectomy. From March 1991 to February 2004, data of all patients undergoing laparoscopic cholecystectomy were prospectively collected. Data of patients with liver cirrhosis were reviewed. The MELD and Child scores were correlated with outcome variables. Of 7859 patients undergoing laparoscopic cholecystectomy, 99 patients (1.3%) exhibited liver cirrhosis, 44 women and 55 men. The mean age was 55 years (range, 28 to 92 years). The mortality rate was 6.3 per cent, morbidity rate 18 per cent, and conversion rate 11 per cent. Laboratory values on 55 patients were available to calculate MELD scores. The mean MELD score was 11 (range, 6 to 23). There was no significant variation in MELD scores with gender (P = 0.61) or cirrhosis etiology, alcoholic and nonalcoholic (P = 0.52). MELD and Child's score correlated well (P < 0.001); however, the risk of complication was not related to the MELD (P = 0.94) or Child-Pugh-Turcotte score (P = 0.26). Morbidity for patients with liver cirrhosis undergoing laparoscopic cholecystectomy remains high. The MELD score is useful for transplant risk stratification for but requires further investigation regarding morbidity prediction for laparoscopic cholecystectomy.
终末期肝病模型(MELD)评分是等待肝移植患者的死亡率预测指标。我们评估了MELD评分预测肝硬化患者行腹腔镜胆囊切除术发病率的能力。从1991年3月至2004年2月,前瞻性收集了所有行腹腔镜胆囊切除术患者的数据。对肝硬化患者的数据进行了回顾。将MELD和Child评分与结局变量进行相关性分析。在7859例行腹腔镜胆囊切除术的患者中,99例(1.3%)患有肝硬化,44例女性,55例男性。平均年龄为55岁(范围28至92岁)。死亡率为6.3%,发病率为18%,中转率为11%。55例患者的实验室值可用于计算MELD评分。平均MELD评分为11分(范围6至23分)。MELD评分在性别(P = 0.61)或肝硬化病因(酒精性和非酒精性,P = 0.52)方面无显著差异。MELD和Child评分相关性良好(P < 0.001);然而,并发症风险与MELD(P = 0.94)或Child-Pugh-Turcotte评分(P = 0.26)无关。肝硬化患者行腹腔镜胆囊切除术的发病率仍然很高。MELD评分对移植风险分层有用,但在预测腹腔镜胆囊切除术的发病率方面需要进一步研究。