McCabe Sarah M, Ma Qing, Slish Judianne C, Catanzaro Linda M, Sheth Neha, DiCenzo Robert, Morse Gene D
Department of Pharmacy Practice and Pharmacotherapy Research Center, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14260, USA.
Clin Pharmacokinet. 2008;47(3):153-72. doi: 10.2165/00003088-200847030-00002.
Hepatic and renal insufficiency due to co-infection, alcoholism, diabetes mellitus, family history, adverse effects of antiretrovirals and other factors are commonly seen in HIV-infected patients. Therefore, the use of antiretrovirals in this patient setting requires attention to the pharmacokinetic issues that clinicians must consider when prescribing highly active antiretroviral therapy for these patients. This review summarizes the current knowledge of the use of antiretrovirals in patients with hepatic or renal impairment, and makes dosing recommendations for this subpopulation of HIV-infected patients.
合并感染、酗酒、糖尿病、家族病史、抗逆转录病毒药物的不良反应及其他因素导致的肝肾功能不全在HIV感染患者中很常见。因此，在此类患者中使用抗逆转录病毒药物时，需要关注临床医生在为这些患者开具高效抗逆转录病毒治疗药物时必须考虑的药代动力学问题。本综述总结了目前关于肝肾功能损害患者使用抗逆转录病毒药物的知识，并为这一HIV感染亚人群提出了给药建议。
