Sartori P C, Darbyshire P J
Department of Haematology, Birmingham Children's Hospital, United Kingdom.
Pediatr Hematol Oncol. 1991 Apr-Jun;8(2):139-45. doi: 10.3109/08880019109033441.
In this paper we describe three infants with Down's syndrome and transient myeloproliferative disorder. The blast cells of all three displayed positive megakaryocytic markers. One patient developed acute megakaryoblastic leukemia in his second year, with blasts identical to those of the initial episode. The other two cases remain well at 12 and 15 months of age.
在本文中,我们描述了三名患有唐氏综合征和短暂性骨髓增殖性疾病的婴儿。所有三名婴儿的原始细胞均显示出阳性巨核细胞标志物。一名患者在第二年发展为急性巨核细胞白血病,其原始细胞与初始发作时的相同。另外两名患者在12个月和15个月大时情况良好。