Lopez-S A, Bell L, Hebert J
Med Res Eng. 1976;12(1):15-7.
An automated procedure for the determination of beta-plus-pre-beta-lipoprotein cholesterol is described and evaluated for mass screening of hyperlipoproteinemias. It is shown that this method fulfills the requirements for an ideal method for primary screening: it can be used in non-fasting samples, is capable of detecting hyperlipoproteinemias characterized by both cholesterol and/or triglyceride abnormalities, is fast, accurate and extremely inexpensive. Evidence is shown that the method is extremely useful for primary screening and, when tested in a coronary screening detection program, gave only 4% false positive and 3.4% false negative results.
本文描述并评估了一种用于测定β-前β脂蛋白胆固醇的自动化程序，用于高脂血症的大规模筛查。结果表明，该方法满足一级筛查理想方法的要求：可用于非空腹样本，能够检测以胆固醇和/或甘油三酯异常为特征的高脂血症，快速、准确且极其廉价。有证据表明，该方法对一级筛查极为有用，在冠状动脉筛查检测项目中进行测试时，假阳性率仅为4%，假阴性率为3.4%。
