Liu Hui, Su Guan-fang
Department of Ophthalmology, Second Hospital of Jilin University, Changchun 130041, China.
Zhonghua Yan Ke Za Zhi. 2007 Nov;43(11):1043-7.
Retinal neovascularization (RNV) is one of the most important causes of blindness. No efficient treatment for RNV is available. Pigment epithelium-derived factor (PEDF) is a natural inhibitor of angiogenesis. It plays an important role in the modulation of ocular neovascularization. It has been demonstrated recently that the ischemia-induced retinal neovascularization can be dramatically inhibited by the recombinant PEDF protein or local viral vector-mediated delivery of PEDF cDNA, which predicts PEDF to be an optional strategy for intractable retinal angiogenic diseases like diabetic retinopathy, retinopathy of prematurity, and central retinal vein occlusion. Therefore, it is necessary to review the biological aspects of PEDF, its effect on the inhibition of angiogenesis and the prospect of using PEDF for the treatment of retinal neovascularization.
视网膜新生血管形成（RNV）是导致失明的最重要原因之一。目前尚无针对RNV的有效治疗方法。色素上皮衍生因子（PEDF）是一种天然的血管生成抑制剂。它在眼部新生血管形成的调节中起重要作用。最近有研究表明，重组PEDF蛋白或局部病毒载体介导的PEDF cDNA递送可显著抑制缺血诱导的视网膜新生血管形成，这预示着PEDF可能是治疗糖尿病性视网膜病变、早产儿视网膜病变和视网膜中央静脉阻塞等难治性视网膜血管生成疾病的一种选择策略。因此，有必要综述PEDF的生物学特性、其对血管生成的抑制作用以及将PEDF用于治疗视网膜新生血管形成的前景。
