van Haren E H, Lammers J W, Festen J, van Herwaarden C L
Department of Pulmonary Diseases, University Hospital, Nijmegen, The Netherlands.
Eur Respir J. 1991 Mar;4(3):301-7.
Spirometry, body plethysmography, maximal expiratory flow-volume curves (MEFV-curves) with air and with heliox (80% He + 20% O2) before and after inhalation of bronchodilators were studied in a group of 20 adult cystic fibrosis (CF) patients. Most of them showed prominent bronchial obstruction and seven also had evidence of restrictive pulmonary disease. Large differences were observed between total lung capacity as measured with body plethysmography and with a helium dilution technique. A calculated air trapping index correlated well with parameters of peripheral airway obstruction. Both inhalation of terbutaline and ipratropium bromide caused dose-related bronchodilatation. Density dependence of expiratory flow increased significantly after terbutaline but not after ipratropium bromide. We conclude that adult CF patients with varying degrees of obstructive and restrictive pulmonary function limitation show a dose-related improvement of lung function after terbutaline and ipratropium bromide with terbutaline being probably more effective on peripheral airways than ipratropium bromide.
对一组20名成年囊性纤维化（CF）患者进行了研究，测定了他们在吸入支气管扩张剂前后的肺活量、体容积描记法、空气及氦氧混合气（80%氦+20%氧）的最大呼气流量-容积曲线（MEFV曲线）。他们中的大多数表现出明显的支气管阻塞，7人还有限制性肺病的证据。通过体容积描记法和氦稀释技术测得的肺总量之间存在很大差异。计算得出的气体潴留指数与外周气道阻塞参数密切相关。吸入特布他林和异丙托溴铵均引起剂量相关的支气管扩张。特布他林吸入后呼气流量的密度依赖性显著增加，而异丙托溴铵吸入后则未增加。我们得出结论，患有不同程度阻塞性和限制性肺功能受限的成年CF患者，吸入特布他林和异丙托溴铵后肺功能有剂量相关的改善，特布他林对外周气道的作用可能比异丙托溴铵更有效。
