Zhang Yuanyuan, Feutl Sebastian, Hauser Ute, Richter-Witte Claudia, Schmorl Philip, Emrich Hinderk M, Dietrich Detlef E
Department of Clinical Psychiatry and Psychotherapy, OE 7110, Medical School Hanover, Carl-Neuberg-Str. 1, D-30625 Hanover, Germany.
Psychiatry Res. 2008 Apr 15;162(3):262-72. doi: 10.1016/j.pscychresns.2007.04.009. Epub 2008 Mar 4.
Memory disturbances found in obsessive-compulsive disorder (OCD) may partially be related to dysfunction of cortico-subcortical circuits. However, it is still unknown how OCD symptomatology is related to memory processing. To explore this question, event-related potentials (ERPs) were recorded in a continuous word-recognition paradigm in OCD patients with either severe or moderate scores on the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) (group S and group M, n=8 each) and in normal healthy controls (n=16). Typically ERPs to repeated items are characterized by more positive waveforms beginning approximately 250 ms post-stimulus. This "old/new effect" has been shown to be relevant for memory processing. The early old/new effect (ca. 300-500 ms) with a frontal distribution is proposed to be a neural correlate of familiarity-based recognition. The late old/new effect (post-500 ms) is assumed to reflect conscious memory retrieval processes. The OCD group S showed a normal early old/new effect and a reduced late old/new effect compared with group M and the control group, but no difference was found between group M and the control group. Source analyses for the late old/new effect showed statistically reduced cerebral activation in the anterior cingulate for OCD group S in contrast to the control group. Additionally, the early old/new effect in OCD group S was negatively correlated with the Y-BOCS total scores, and the late old/new effect was negatively correlated with obsession sub-scores. The severely, not moderately, ill OCD patients showed an impaired conscious recollection of the word-to-be-remembered, which suggested an impairment of working memory capacity in these patients due to a dysfunction in the frontal and cingulate cortex.
强迫症（OCD）中发现的记忆障碍可能部分与皮质-皮质下回路功能障碍有关。然而，OCD症状学与记忆处理之间的关系仍不清楚。为了探究这个问题，我们在一个连续单词识别范式中记录了事件相关电位（ERP），该范式的研究对象包括耶鲁-布朗强迫症量表（Y-BOCS）评分重度或中度的OCD患者（S组和M组，每组n = 8）以及正常健康对照者（n = 16）。通常，对重复项目的ERP特征是在刺激后约250毫秒开始出现更正向的波形。这种“新旧效应”已被证明与记忆处理有关。具有额叶分布的早期新旧效应（约300 - 500毫秒）被认为是基于熟悉度识别的神经关联。晚期新旧效应（500毫秒后）被假定反映有意识的记忆检索过程。与M组和对照组相比，OCD的S组早期新旧效应正常，但晚期新旧效应降低，而M组和对照组之间未发现差异。晚期新旧效应的源分析显示，与对照组相比，OCD的S组前扣带回的大脑激活在统计学上有所降低。此外，OCD的S组早期新旧效应与Y-BOCS总分呈负相关，晚期新旧效应与强迫观念子评分呈负相关。重度而非中度患病的OCD患者表现出对要记忆单词的有意识回忆受损，这表明这些患者由于额叶和扣带回皮质功能障碍而导致工作记忆能力受损。
