Lu Run-Chao, Cao Ao-Neng, Lai Lu-Hua, Xiao Jin-Xin
Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
Colloids Surf B Biointerfaces. 2008 Jun 15;64(1):98-103. doi: 10.1016/j.colsurfb.2008.01.009. Epub 2008 Jan 18.
The interactions of proteins with fluorinated/hydrogenated surfactants were investigated by circular dichroism and turbidity measurement. Pairs of fluorinated and hydrogenated surfactants with similar critical micelle concentrations (cmc), including sodium perfluorooctanoate/sodium decylsulfate and lithium perfluorononanoate/sodium dodecylsulfate were compared in view of their interactions with proteins including BSA, lysozyme, beta-lactoglobulin and ubiquitin. It was found that fluorinated surfactants exhibited stronger interactions with proteins than hydrogenated ones, which, however, depended on the structures of both proteins and surfactant molecules. If the proteins are very stable, or the surfactant-protein interactions are very strong, such differences between the two kinds of surfactants might be indistinguishable.
通过圆二色性和浊度测量研究了蛋白质与氟化/氢化表面活性剂的相互作用。比较了具有相似临界胶束浓度（cmc）的氟化和氢化表面活性剂对，包括全氟辛酸钠/癸基硫酸钠和全氟壬酸钠锂/十二烷基硫酸钠，考察了它们与蛋白质（包括牛血清白蛋白、溶菌酶、β-乳球蛋白和泛素）的相互作用。结果发现，氟化表面活性剂与蛋白质的相互作用比氢化表面活性剂更强，然而，这取决于蛋白质和表面活性剂分子的结构。如果蛋白质非常稳定，或者表面活性剂与蛋白质的相互作用非常强，那么这两种表面活性剂之间的差异可能无法区分。
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