Groeneboer S, Pastoureau P, Vignon E, Vander Cruyssen B, Elewaut D, Verbruggen G
Department of Rheumatology, Ghent University Hospital, University of Ghent, Ghent, Belgium.
Osteoarthritis Cartilage. 2008 Sep;16(9):986-93. doi: 10.1016/j.joca.2008.01.005. Epub 2008 Mar 4.
To evaluate the in vivo chondroprotective effect of cyclodextrin polysulphate (CDPS) in a rabbit model of experimental osteoarthritis (OA).
Experimental OA was induced in rabbits by anterior cruciate ligament transection (ACLT). Forty-eight hours post-surgery, the rabbits were randomised into three treatment groups (n=15 in each group) and a sham-operated control group. The rabbits were either injected subcutaneously with saline, 0.25 mg/kg CDPS or 1 mg/kg CDPS once a week for a period of 12 weeks, and their weight was monitored as a parameter for their general status. The animals were then sacrificed for macroscopic and histological assessment of the knee joints.
At the lowest dose, CDPS treatment was unable to induce a significant improvement of cartilage degradation vs the saline control in the experimentally induced knee OA. However, subcutaneous injections of 1 mg/kg CDPS induced a marked inhibition (P<0.05) of osteophyte formation. Additionally, a significant reduction of cartilage degradation revealed an overall chondroprotective effect of CDPS at a concentration of 1 mg/kg. No significant effects on weight gain were noted.
Systemic administration of CDPS is able to protect cartilage in vivo and can therefore be considered as a chondroprotective agent with structure modifying capacities.
评估环糊精多硫酸盐（CDPS）在兔实验性骨关节炎（OA）模型中的体内软骨保护作用。
通过切断前交叉韧带（ACLT）诱导兔实验性OA。术后48小时，将兔随机分为三个治疗组（每组n = 15）和一个假手术对照组。兔每周皮下注射一次生理盐水、0.25 mg/kg CDPS或1 mg/kg CDPS，持续12周，并监测其体重作为整体状况的参数。然后处死动物，对膝关节进行宏观和组织学评估。
在最低剂量下，与生理盐水对照组相比，CDPS治疗在实验性诱导的膝OA中未能显著改善软骨降解。然而，皮下注射1 mg/kg CDPS可显著抑制（P<0.05）骨赘形成。此外，软骨降解的显著减少表明CDPS在浓度为1 mg/kg时具有整体软骨保护作用。未观察到对体重增加的显著影响。
全身给予CDPS能够在体内保护软骨，因此可被视为具有结构修饰能力的软骨保护剂。
