Held Werner, Mariuzza Roy A
Ludwig Institute for Cancer Research, Lausanne Branch and University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland.
Nat Rev Immunol. 2008 Apr;8(4):269-78. doi: 10.1038/nri2278. Epub 2008 Feb 29.
The conventional wisdom is that cell-surface receptors interact with ligands expressed on other cells to mediate cell-to-cell communication (trans interactions). Unexpectedly, it has recently been found that two classes of receptors specific for MHC class I molecules not only interact with MHC class I molecules expressed on opposing cells, but also with those on the same cell. These cis interactions are a feature of immunoreceptors that inhibit, rather than activate, cellular functions. Here, we review situations in which cis interactions have been observed, the characteristics of receptors that bind in trans and cis, and the biological roles of cis recognition.
传统观点认为,细胞表面受体与其他细胞上表达的配体相互作用以介导细胞间通讯(反式相互作用)。出乎意料的是,最近发现两类对MHC I类分子具有特异性的受体不仅能与相对细胞上表达的MHC I类分子相互作用,还能与同一细胞上的此类分子相互作用。这些顺式相互作用是抑制而非激活细胞功能的免疫受体的一个特征。在此,我们综述了观察到顺式相互作用的情况、能进行反式和顺式结合的受体的特性以及顺式识别的生物学作用。