Dustin Michael L
Kennedy Institute of Rheumatology, The University of Oxford, Oxford, UK.
Fac Rev. 2023 Oct 16;12:25. doi: 10.12703/r/12-25. eCollection 2023.
The T cell receptor is a multi-subunit complex that carries out a range of recognition tasks for multiple lymphocyte types and translates recognition into signals that regulate survival, growth, differentiation, and effector functions for innate and adaptive host defense. Recent advances include the cryo-electron microscopy-based structure of the extracellular and transmembrane components of the complex, new information about coupling to intracellular partners, lateral associations in the membrane that all add to our picture of the T cell signaling machinery, and how signal termination relates to effector function. This review endeavors to integrate structural and biochemical information through the lens of the immunological synapse- the critical interface with the antigen-presenting cell.
T细胞受体是一种多亚基复合体，它为多种淋巴细胞类型执行一系列识别任务，并将识别转化为信号，这些信号调节固有和适应性宿主防御的存活、生长、分化及效应功能。最近的进展包括基于冷冻电子显微镜的该复合体细胞外和跨膜成分的结构、与细胞内伙伴偶联的新信息、膜中的侧向关联，所有这些都丰富了我们对T细胞信号传导机制的认识，以及信号终止与效应功能的关系。本综述试图通过免疫突触（与抗原呈递细胞的关键界面）这一视角整合结构和生化信息。
