[对水黄皮根治疗实验性胃溃疡有效部位的筛选]
[Screening of effective fraction on experimental gastric ulcer from Pongamia pinnata roots].
作者信息
Liu Ke-Yun, Zhu Yi, Chen Guo-Biao, Dong Zhi, Zhao Yu-Mei, Li Bei, Liu Chun, Li Jing
机构信息
Department of Pharmacology, Institute for Drug Control of Hainan province, Haikou 570216, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2007 Nov;32(21):2286-8.
OBJECTIVE
To study the effect of extract from Pongamia pinnata roots on experimental gastric ulcer and screen the effective fraction.
METHOD
The models of gastric mucosa damage were induced by absolute alcohol in rats and reserpine in mice to observed the effect of ethyl alcohol extract from P. pinnata roots (PRE) and different parts on experimental gastric ulcer.
RESULT
PRE, acetic ether extract and n-butanol extract could significantly inhibit the gastric mucosa damage induced by absolute alcohol in rats and reserpine in mice. In absolute alcohol models the gastric ulcer rates of inhibition were 86.4%, 85.4%, 11.5%, respectively. In reserpine models the gastric ulcer rates of inhibition were 37.8%, 33.8%, 19.7%, respectively.
CONCLUSION
PRE, acetic ether extract and n-butanol extract could significantly inhibit the gastric mucosa damage induced by absolute alcohol in rats and reserpine in mice. Acetic ether extract from P. pinnata roots has the best effect on experimental gastric ulcer.
目的
研究水黄皮根提取物对实验性胃溃疡的作用并筛选有效部位。
方法
采用无水乙醇致大鼠胃黏膜损伤模型和利血平致小鼠胃黏膜损伤模型，观察水黄皮根乙醇提取物（PRE）及其不同部位对实验性胃溃疡的影响。
结果
PRE、乙酸乙酯提取物和正丁醇提取物能显著抑制无水乙醇所致大鼠胃黏膜损伤及利血平所致小鼠胃黏膜损伤。在无水乙醇模型中，抑制胃溃疡的发生率分别为86.4%、85.4%、11.5%。在利血平模型中，抑制胃溃疡的发生率分别为37.8%、33.8%、19.7%。
结论
PRE、乙酸乙酯提取物和正丁醇提取物能显著抑制无水乙醇所致大鼠胃黏膜损伤及利血平所致小鼠胃黏膜损伤。水黄皮根乙酸乙酯提取物对实验性胃溃疡效果最佳。
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