用锝-99m标记鞣酸用于胃溃疡的诊断。

Labeling of tannic Acid with technetium-99m for diagnosis of stomach ulcer.

作者信息

Ibrahim I T, El-Tawoosy M, Talaat H M

机构信息

Radioisotopes Production and Radioactive Sources Division, Labelled Compounds Department, Hot Laboratories Center, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt.

出版信息

ISRN Pharm. 2011;2011:578570. doi: 10.5402/2011/578570. Epub 2011 Jul 19.

DOI:10.5402/2011/578570

PMID:22389852

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3263727/

Abstract

Tannic acid is a polyphenolic compound that could be labeled with technetium-99m. To produce about 90% yield of (99m)Tc-tannic acid in acidic media (pH), the conditions required were 150 μg tin chloride, 30 min reaction time, and 200 μg of the substrate. (99m)Tc-tannic was stable for 6 h. Oral biodistribution of (99m)Tc-tannic showed that it concentrated in the stomach ulcer to reach about 50% of the total injected dose at 1 h after orall administration. This concentration of (99m)Tc-tannic in stomach ulcer may be sufficient to radio-image the presence of ulcer in the stomach.

摘要

单宁酸是一种可被锝-99m标记的多酚化合物。在酸性介质（pH值）中制备锝-99m单宁酸的产率约为90%时，所需条件为150μg氯化亚锡、30分钟反应时间和200μg底物。锝-99m单宁酸在6小时内保持稳定。锝-99m单宁酸的口服生物分布表明，口服给药1小时后，它在胃溃疡中浓聚，达到注射总剂量的约50%。胃溃疡中这种锝-99m单宁酸的浓度可能足以对胃内溃疡的存在进行放射性成像。