Mazepa M A
Vestn Akad Med Nauk SSSR. 1991(4):57-61.
The review presents literature data on studies into fibronectin in rheumatic diseases of immunocomplex genesis, its contribution to the development of abnormalities in the immune system and to hemostatic processes in the diseases. The role of fibronectin in the clearance of immune complexes, disturbed metabolism products of connective tissue, fibrin, and its monomers, cell membrane receptor proteins is emphasized. Extracorporeal heparin precipitation by using fibronectin is ascertained to be promising in removing plasma proteins in rheumatic immunocomplex diseases. A possible involvement of fibronectin in the fixation of immune complexes and DNA on the basal membranes, followed by immunocomplex inflammation, in the fibrin-induced R protein retention in the body, suppression of local immunity reactions, and development of joint ankylosis in rheumatic arthritis.
该综述介绍了关于免疫复合物性风湿性疾病中纤连蛋白的研究的文献数据，及其在疾病免疫系统异常发展和止血过程中的作用。强调了纤连蛋白在免疫复合物、结缔组织代谢产物紊乱、纤维蛋白及其单体、细胞膜受体蛋白清除中的作用。已确定使用纤连蛋白进行体外肝素沉淀在去除风湿性免疫复合物疾病中的血浆蛋白方面具有前景。纤连蛋白可能参与免疫复合物和DNA在基底膜上的固定，继而引发免疫复合物炎症，参与纤维蛋白诱导的R蛋白在体内的潴留、局部免疫反应的抑制以及风湿性关节炎中关节强直的发展。
