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苏丹肾衰竭患者血液透析和腹膜透析后的血液学变化

Hematological changes post-hemo and peritoneal dialysis among renal failure patients in Sudan.

作者信息

Mohamed Ali Mohamed Siddig, Babiker Muna Abbas, Merghani Leena Babiker, Ali Fadl Aljabbar Al Taib, Abdulmajeed Mekki Hamad

机构信息

Department of Hematology, Faculty of Medical Laboratory Sciences, AI Neelain University, Sudan.

出版信息

Saudi J Kidney Dis Transpl. 2008 Mar;19(2):274-9.

Abstract

The objective of the study was to assess the changes that occur in various hematological parameters that may occur in renal failure patients after hemo and peritoneal dialysis sessions. The study was carried out at the AI Neelain University, Khartoum, Sudan. Blood samples were collected from 180 renal failure patients undergoing hemo and peritoneal dialysis (90 each) before and after dialysis sessions. The samples were tested for complete blood count, prothrombin time and activated partial thromboplastin time by the manual calibrated techniques. The study demonstrated an increase of hemoglobin, hematocrit and red cell count after both hemo and peritoneal dialysis. The mean corpuscular hemoglobin and hemoglobin concentration showed mild increase after peritoneal dialysis and slight decrease after hemodialysis. Leukocyte and platelet counts also showed mild increase after hemodialysis, while the prothrombin and activated partial thromboplastin times were significantly prolonged. Our study shows that most of the hematological parameters as well as prothrombin and partial thromboplastin times increased after a dialysis session. Therefore, it is recommended that all patients be screened appropriately before and after dialysis to avoid complications.

摘要

该研究的目的是评估血液透析和腹膜透析治疗后,肾衰竭患者各项血液学参数可能发生的变化。该研究在苏丹喀土穆的阿尼尔因大学开展。从180例接受血液透析和腹膜透析的肾衰竭患者(各90例)透析治疗前后采集血样。采用手工校准技术对样本进行全血细胞计数、凝血酶原时间和活化部分凝血活酶时间检测。研究表明,血液透析和腹膜透析后血红蛋白、血细胞比容和红细胞计数均升高。平均红细胞血红蛋白含量和血红蛋白浓度在腹膜透析后轻度升高,在血液透析后略有下降。白细胞和血小板计数在血液透析后也轻度升高,而凝血酶原时间和活化部分凝血活酶时间显著延长。我们的研究表明,透析治疗后大多数血液学参数以及凝血酶原时间和部分凝血活酶时间均升高。因此,建议在透析前后对所有患者进行适当筛查,以避免并发症。

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