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高剂量率组织间近距离放射治疗植入的定性剂量学和放射生物学评估

Qualitative dosimetric and radiobiological evaluation of high - dose - rate interstitial brachytherapy implants.

作者信息

Kehwar Than S, Akber Syed F, Passi Kamlesh

机构信息

Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA.

出版信息

Int J Med Sci. 2008 Feb 19;5(1):41-9. doi: 10.7150/ijms.5.41.

DOI:10.7150/ijms.5.41
PMID:18311328
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2253950/
Abstract

Radiation quality indices (QI), tumor control probability (TCP), and normal tissue complication probability(NTCP) were evaluated for ideal single and double plane HDR interstitial implants. In the analysis, geometrically-optimized at volume (GOV) treatment plans were generated for different values of inter-source-spacing (ISS) within the catheter, inter-catheter-spacing (ICS), and inter-plane-spacing (IPS) for single - and double - plane implants. The dose volume histograms (DVH) were generated for each plan, and the coverage volumes of 100%, 150%, and 200% were obtained to calculate QIs, TCP, and NTCP. Formulae for biologically effective equivalent uniform dose (BEEUD), for tumor and normal tissues, were derived to calculate TCP and NTCP. Optimal values of QIs, except external volume index (EI), and TCP were obtained at ISS = 1.0 cm, and ICS = 1.0 cm, for single-plane implants, and ISS = 1.0 cm, ICS = 1.0 cm, and IPS = 0.75 to 1.25 cm, for double - plane implants. From this study, it is assessed that ISS = 1.0 cm, ICS = 1.0 cm, for single - plane implant and IPS between 0.75 cm to 1.25 cm provide better dose conformity and uniformity.

摘要

针对理想的单平面和双平面高剂量率近距离植入，评估了辐射质量指数（QI）、肿瘤控制概率（TCP）和正常组织并发症概率（NTCP）。在分析中，针对单平面和双平面植入，在导管内不同的源间距（ISS）、导管间距（ICS）和平面间距（IPS）值下生成了几何体积优化（GOV）治疗计划。为每个计划生成剂量体积直方图（DVH），并获取100%、150%和200%的覆盖体积以计算QI、TCP和NTCP。推导了肿瘤和正常组织的生物等效均匀剂量（BEEUD）公式以计算TCP和NTCP。对于单平面植入，在ISS = 1.0 cm和ICS = 1.0 cm时获得了除外部体积指数（EI）外的QI和TCP的最佳值；对于双平面植入，在ISS = 1.0 cm、ICS = 1.0 cm和IPS = 0.75至1.25 cm时获得了最佳值。通过这项研究评估得出，对于单平面植入，ISS = 1.0 cm、ICS = 1.0 cm，对于双平面植入，IPS在0.75 cm至1.25 cm之间可提供更好的剂量适形性和均匀性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b9e/2253950/0e7e8471cf64/ijmsv05p0041g08.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b9e/2253950/92a1a3862d5c/ijmsv05p0041g02.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b9e/2253950/6530ed0f7170/ijmsv05p0041g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b9e/2253950/95b707cafb8a/ijmsv05p0041g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b9e/2253950/85a01b12eeff/ijmsv05p0041g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b9e/2253950/0e7e8471cf64/ijmsv05p0041g08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b9e/2253950/ca3cb4d57772/ijmsv05p0041g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b9e/2253950/92a1a3862d5c/ijmsv05p0041g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b9e/2253950/24b262969ba2/ijmsv05p0041g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b9e/2253950/f5a87b1b888a/ijmsv05p0041g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b9e/2253950/6530ed0f7170/ijmsv05p0041g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b9e/2253950/95b707cafb8a/ijmsv05p0041g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b9e/2253950/85a01b12eeff/ijmsv05p0041g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b9e/2253950/0e7e8471cf64/ijmsv05p0041g08.jpg

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本文引用的文献

1
Analytical approach to estimate normal tissue complication probability using best fit of normal tissue tolerance doses into the NTCP equation of the linear quadratic model.通过将正常组织耐受剂量最佳拟合到线性二次模型的正常组织并发症概率（NTCP）方程中来估计正常组织并发症概率的分析方法。
J Cancer Res Ther. 2005 Jul-Sep;1(3):168-79. doi: 10.4103/0973-1482.19597.
2
A proof that uniform dose gives the greatest TCP for fixed integral dose in the planning target volume.在计划靶体积中，对于固定的积分剂量，均匀剂量可产生最大肿瘤控制概率的证明。
Phys Med Biol. 1994 Nov;39(11):2091-8. doi: 10.1088/0031-9155/39/11/018.
3
Practical considerations in using calculated healthy-tissue complication probabilities for treatment-plan optimization.
Role of high dose rate interstitial brachytherapy in early and locally advanced squamous cell carcinoma of buccal mucosa.
高剂量率组织间近距离放射疗法在颊黏膜早期及局部晚期鳞状细胞癌中的作用
Springerplus. 2014 Oct 9;3:590. doi: 10.1186/2193-1801-3-590. eCollection 2014.
4
A brachytherapy plan evaluation tool for interstitial applications.一种用于间质应用的近距离治疗计划评估工具。
Adv Bioinformatics. 2014;2014:376207. doi: 10.1155/2014/376207. Epub 2014 Feb 9.
5
Treatment planning methods in high dose rate interstitial brachytherapy of carcinoma cervix: a dosimetric and radiobiological analysis.宫颈癌高剂量率组织间近距离治疗的治疗计划方法：剂量学与放射生物学分析
ISRN Oncol. 2014 Jan 23;2014:125020. doi: 10.1155/2014/125020. eCollection 2014.
6
Biological effective doses in the intracavitary high dose rate brachytherapy of cervical cancer.宫颈癌腔内高剂量率近距离放疗中的生物有效剂量
J Contemp Brachytherapy. 2011 Dec;3(4):188-92. doi: 10.5114/jcb.2011.26469. Epub 2011 Dec 30.
Int J Radiat Oncol Biol Phys. 1999 May 1;44(2):439-47. doi: 10.1016/s0360-3016(99)00014-0.
4
Evaluation of the dose uniformity for double-plane high dose rate interstitial breast implants with the use of dose reference points and dose non-uniformity ratio.使用剂量参考点和剂量不均匀率评估双平面高剂量率乳腺组织间插植的剂量均匀性。
Radiother Oncol. 2000 Mar;54(3):213-20. doi: 10.1016/s0167-8140(99)00170-x.
5
A conformal index (COIN) to evaluate implant quality and dose specification in brachytherapy.一种用于评估近距离放射治疗中植入物质量和剂量规格的适形指数（COIN）。
Int J Radiat Oncol Biol Phys. 1998 Jan 15;40(2):515-24. doi: 10.1016/s0360-3016(97)00732-3.
6
Effect of geometrical optimization on the treatment volumes and the dose homogeneity of biplane interstitial brachytherapy implants.几何优化对双平面组织间近距离放射治疗植入物的治疗体积和剂量均匀性的影响。
Radiother Oncol. 1997 Oct;45(1):71-6. doi: 10.1016/s0167-8140(97)00143-6.
7
Pulsed dose rate and fractionated high dose rate brachytherapy: choice of brachytherapy schedules to replace low dose rate treatments.脉冲剂量率和分次高剂量率近距离放射治疗：替代低剂量率治疗的近距离放射治疗方案选择
Int J Radiat Oncol Biol Phys. 1996 Jan 15;34(2):497-505. doi: 10.1016/0360-3016(95)02054-3.
8
Comments on the article 'A model for calculating tumour control probability in radiotherapy including the effects of inhomogeneous distributions of dose and clonogenic cell density'.
Phys Med Biol. 1995 Oct;40(10):1735-8. doi: 10.1088/0031-9155/40/10/015.
9
Concept of dose nonuniformity in interstitial brachytherapy.
Int J Radiat Oncol Biol Phys. 1993 Jun 15;26(3):519-27. doi: 10.1016/0360-3016(93)90971-w.
10
A model for calculating tumour control probability in radiotherapy including the effects of inhomogeneous distributions of dose and clonogenic cell density.
Phys Med Biol. 1993 Jun;38(6):653-66. doi: 10.1088/0031-9155/38/6/001.