Dimitropoulos Anastasia, Schultz Robert T
Developmental Neuroimaging Laboratory, Yale Child Study Center, Yale University School of Medicine, New Haven, CT, USA.
J Autism Dev Disord. 2008 Oct;38(9):1642-53. doi: 10.1007/s10803-008-0546-x. Epub 2008 Feb 29.
Prader-Willi syndrome (PWS) is a neurodevelopmental disorder characterized by hyperphagia and food preoccupations. Although dysfunction of the hypothalamus likely has a critical role in hyperphagia, it is only one of several regions involved in the regulation of eating. The purpose of this research was to examine food-related neural circuitry using functional magnetic resonance imaging in individuals with PWS and matched controls. Individuals with PWS showed increased activation in neural circuitry known to mediate hunger and motivation (hypothalamus, OFC) in response to high- versus low-calorie foods and in comparison to controls. This suggests neural circuitry for PWS is abnormally activated during hunger, particularly for high-calorie foods, and may mediate abnormally strong hunger states, therefore playing a significant role in PWS-induced hyperphagia.
普拉德-威利综合征（PWS）是一种以食欲亢进和对食物过度关注为特征的神经发育障碍。虽然下丘脑功能障碍可能在食欲亢进中起关键作用，但它只是参与饮食调节的几个区域之一。本研究的目的是使用功能磁共振成像检查普拉德-威利综合征患者和匹配对照组中与食物相关的神经回路。与对照组相比，普拉德-威利综合征患者在已知介导饥饿和动机的神经回路（下丘脑、眶额皮质）中，对高热量食物与低热量食物的反应中表现出激活增加。这表明普拉德-威利综合征的神经回路在饥饿期间异常激活，特别是对于高热量食物，并且可能介导异常强烈的饥饿状态，因此在普拉德-威利综合征引起的食欲亢进中起重要作用。
