Nagamachi Shigeki, Wakamatsu Hideyuki, Fujita Seigo, Nishii Ryuichi, Kamimura Kiyohisa, Kiyohara Shogo, Futami Shigemi, Onitsuka Hisamitsu, Nagoshi Yasuko, Tamura Shozo, Kawai Keiichi, Arita Hideo
Department of Radiology, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan.
Ann Nucl Med. 2008 Feb;22(2):115-22. doi: 10.1007/s12149-007-0091-2. Epub 2008 Mar 3.
The objective of the present study is to investigate the correlations across various types of interface software for (201)Tl gated myocardial perfusion SPECT (MPS) in calculating two common diastolic function parameters (DFx), peak-filling rates (PFR), and time-to-peak filling (TTPF).
A total of 109 patients (66 men and 43 women; age 35-78 years) were studied. All patients were classified into three groups (i.e., ND, no-defect group; SD, small-defect group; LD, large-defect group) to clarify the influence of perfusion defects possibly affecting the analysis. Two kinds of available software, namely, quantitative gated SPECT (QGS2) and perfusion and functional analysis for gated SPECT (pFAST2) with cardioGRAF were used to obtain PFR and TTPF. Finally, we analyzed the correlation between DFx obtained with the two different kinds of software.
The values of LVEF, PFR, and TTPF were assessed in all patients. In both the ND (correlation coefficients were 0.92, 0.79, and 0.99, respectively) and SD groups (correlation coefficients were 0.74, 0.88, and 0.98, respectively), a strong correlation was observed. In contrast, PFR did not show a significant correlation in the LD group.
With the two different kinds of software, QGS2 and pFAST2, the calculated PFR was almost equal and showed good correlations in both ND and SD groups. In contrast, the numerical value varied between the two methods, and its correlation was poor in the LD group. However, TTPF showed a good correlation regardless of the presence of perfusion defects, and the values were equal. TTPF was confirmed to be a stable diastolic index across the two kinds of software, QGS2 and pFAST2, in (201)Tl gated MPS.
本研究的目的是调查用于（201）铊门控心肌灌注单光子发射计算机断层扫描（MPS）的各种类型界面软件在计算两个常见舒张功能参数（DFx）、峰值充盈率（PFR）和峰值充盈时间（TTPF）方面的相关性。
共研究了109例患者（66例男性和43例女性；年龄35 - 78岁）。所有患者被分为三组（即ND，无缺陷组；SD，小缺陷组；LD，大缺陷组），以阐明灌注缺陷可能对分析产生的影响。使用两种可用软件，即定量门控SPECT（QGS2）和带有cardioGRAF的门控SPECT灌注与功能分析（pFAST2）来获取PFR和TTPF。最后，我们分析了用两种不同软件获得的DFx之间的相关性。
对所有患者评估了左心室射血分数（LVEF）、PFR和TTPF的值。在ND组（相关系数分别为0.92、0.79和0.99）和SD组（相关系数分别为0.74、0.88和0.98）中，均观察到强相关性。相比之下，PFR在LD组中未显示出显著相关性。
使用QGS2和pFAST2这两种不同软件，计算出的PFR在ND组和SD组中几乎相等且显示出良好的相关性。相比之下，两种方法的数值有所不同，且在LD组中其相关性较差。然而，无论是否存在灌注缺陷，TTPF均显示出良好的相关性，且数值相等。在（201）铊门控MPS中，TTPF被证实是QGS2和pFAST2这两种软件中稳定的舒张指标。
