Fernandes A R, Rose M, Charlton C
Central Science Laboratory, Sand Hutton, York YO41 1LZ, UK.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008 Mar;25(3):364-72. doi: 10.1080/02652030701564548.
Nonylphenol is a recognized environmental contaminant, but it is unclear whether its occurrence in food arises only through environmental pathways or also during the processing or packaging of food, as there are reports that indicate that materials in contact with food such as rubber products and polyvinylchloride wraps can contain nonylphenol. A review of the literature has highlighted the scarcity of robust analytical methodology or data on the occurrence of nonylphenol in packaging materials. This paper describes a methodology for the determination of nonylphenol in a variety of packaging materials, which includes plastics, paper and rubber. The method uses either Soxhlet extraction or dissolution followed by solvent extraction (depending on the material type), followed by purification using adsorption chromatography. Procedures were internally standardized using 13C-labelled nonylphenol and the analytes were measured by gas chromatography-mass spectrometry. The method is validated and data relating to quality parameters such as limits of detection, recovery, precision and linearity of measurement are provided. Analysis of a range of 25 food-contact materials found nonylphenol at concentrations of 64-287 microg g(-1) in some polystyrene and polyvinylchloride samples. Far lower concentrations (<0.03-1.4 microg g(-1)) were detected in the other materials. It is possible that occurrence at the higher levels has the potential for migration to food.
壬基酚是一种公认的环境污染物，但目前尚不清楚其在食品中的出现仅仅是通过环境途径，还是也在食品加工或包装过程中产生，因为有报告表明，与食品接触的材料，如橡胶制品和聚氯乙烯包装材料，可能含有壬基酚。对文献的综述突出了关于包装材料中壬基酚存在情况的可靠分析方法或数据的匮乏。本文描述了一种测定多种包装材料中壬基酚的方法，这些材料包括塑料、纸张和橡胶。该方法根据材料类型，采用索氏提取或溶解后进行溶剂萃取，随后通过吸附色谱法进行纯化。使用13C标记的壬基酚对程序进行内部标准化，并通过气相色谱 - 质谱法测量分析物。该方法经过验证，并提供了与质量参数相关的数据，如检测限、回收率、精密度和测量线性度。对一系列25种食品接触材料的分析发现，一些聚苯乙烯和聚氯乙烯样品中壬基酚的浓度为64 - 287微克/克。在其他材料中检测到的浓度要低得多（<0.03 - 1.4微克/克）。较高水平的壬基酚有可能迁移到食品中。
